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Research paper

Quantifying the roles of host movement and vector dispersal in the transmission of vector-borne diseases of livestock

Diseases which are transmitted by the bites of insects can be spread to new locations through the movement of both infected insects and infected hosts. The importance of these routes has implications for disease control, because we can often restrict host movement, and so…
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Research paper

Mechanistic model for predicting the seasonal abundance of Culicoides biting midges and the impacts of insecticide control

Understanding seasonal patterns of abundance of insect vectors is important for optimisation of control strategies of vector-borne diseases. Environmental drivers such as temperature, humidity and photoperiod influence vector abundance, but it is not generally known how…
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Research paper

Activation of gga-miR-155 by reticuloendotheliosis virus T strain and its contribution to transformation

The v-rel oncoprotein encoded by reticuloendotheliosis virus T strain (Rev-T) is a member of the rel/NF-kappaB family of transcription factors capable of transformation of primary chicken spleen and bone marrow cells. Rapid transformation of avian haematopoietic cells by v…
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Research paper

Highly diverse population of Picornaviridae and other members of the Picornavirales, in Cameroonian fruit bats

The order Picornavirales represents a diverse group of positive-stranded RNA viruses with small non-enveloped icosahedral virions. Recently, bats have been identified as an important reservoir of several highly pathogenic human viruses. Since many members of the…
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Research paper

Thermal inactivation of foot-and-mouth disease virus in extruded pet food

The risk of importing foot-and-mouth disease, a highly contagious viral disease of livestock, severely restricts trade and investment opportunities in many developing countries where the virus is present. This study was designed to investigate the inactivation of foot-and…
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Research paper

VP1 sequencing protocol for foot and mouth disease virus molecular epidemiology

Nucleotide sequences of field strains of foot and mouth disease virus (FMDV) contribute to our understanding of the distribution and evolution of viral lineages that circulate in different regions of the world. This paper outlines a practical reverse-transcription polymerase…
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Research paper

Revisiting the taxonomical classification of porcine circovirus type 2 (PCV2): still a real challenge

Background: PCV2 has emerged as one of the most devastating viral infections of swine farming, causing a relevant economic impact due to direct losses and control strategies expenses. Epidemiological and experimental studies have evidenced that genetic diversity is…
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Research paper

Differential expression of microRNAs in Marek's disease virus-transformed T-lymphoma cell lines

MicroRNAs (miRNAs) are increasingly recognized to play crucial roles in regulation of gene expression in different biological events, including many sporadic forms of cancer. However, despite the involvement of several viruses in inducing cancer, only a limited number of…
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Article

Pandemic threat to humans from common bird flu virus H9N2 better understood

Experiments by researchers at The Pirbright Institute have identified the molecular mechanisms that enable H9N2 viruses - the most common type of avian influenza (bird flu) virus - to infect humans, helping improve risk assessments for its potential to cause pandemic…
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Article

First industry guidance on safe working with arthropods and GM insects launched

The first industry guidance on working safely with arthropods and genetically modified (GM) insects was officially launched today (21 April, 2017) at The Pirbright Institute. `Safe working with arthropods: Containment and control for work with uninfected, infected and…
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