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Comparison of cellular and humoral immunoassays for the assessment of summer eczema in horses

The objective of this study was to compare and analyze three common diagnostic methods for summer eczema (SE) in horses, an allergic dermatitis caused by bites of Culicoides spp. Nine horses with a medical history of SE and nine control animals were intradermally challenged…

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Differential diagnosis of bluetongue in cattle and sheep

In 2006, bluetongue virus serotype 8 (BTV-8) caused the first recorded bluetongue outbreak in northern Europe. This occurred in countries with no previous history of bluetongue virus incursion, including the Netherlands, Belgium and Germany. Following a halt to disease…

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A duplex RT-PCR assay for detection of genome segment 7 (VP7 gene) from 24 BTV serotypes

Since 1998, six distinct serotypes of Bluetongue virus (BTV) have invaded Southern and Central Europe, persisting in some regions for up to 6 years and resulting in the deaths of >1.8 million sheep. Rapid and reliable methods of virus detection and identification play an…

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Collection and analysis of salivary proteins from the biting midge Culicoides nubeculosus (Diptera: Ceratopogonidae)

Salivary proteins of hematophagous Culicoides spp. are thought to play an important role in pathogen transmission and skin hypersensitivity. Analysis of these proteins, however, has been problematic due to the difficulty in obtaining adequate amounts of secreted Culicoides…

Maintaining global freedom from rinderpest

The 3rd International Meeting on ‘Maintaining Global Freedom from Rinderpest’ was held in Kathmandu, Nepal on 14-16 June 2017. The meeting brought together a global audience, including a group of scientists from The Pirbright Institute, who discussed plans for controlling…

World Zoonoses Day: New study highlights how Pirbright research helps protect animals and humans

An international research collaboration exploring new ways to control influenza viruses led by The Pirbright Institute has provided insights that could lead to the design of better vaccines for animals and humans. Pirbright scientists are highlighting this research today -…

CMO report encourages use of genome sequencing across healthcare systems

Today the Government’s Chief Medical Officer, Professor Dame Sally Davies, published her annual report “ Generation Genome” - with a call to embrace genome sequencing and mainstream it into modern health care. The report highlights the many areas to which genetic sequencing…

News feature: the emergence of lumpy skin disease in Europe

Lumpy skin disease (LSD) is an important disease of cattle which was first seen in southern Africa in the 1920s. It is now found throughout Africa, and more recently has spread into the Middle East. In 2015 the disease entered Europe for the first time, resulting in the…

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Identification of cross-reacting T-cell epitopes in structural and non-structural proteins of swine and pandemic H1N1 influenza A virus strains in pigs

Heterologous protection against swine influenza viruses (SwIVs) of different lineages is an important concern for the pig industry. Cross-protection between 'avian-like' H1N1 and 2009 pandemic H1N1 lineages has been observed previously, indicating the involvement of cross…

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Comparative phenotypic and functional analyses of the effects of autologous plasma and recombinant human macrophage-colony stimulating factor (M-CSF) on porcine monocyte to macrophage differentiation

Porcine monocyte-derived macrophages (moM?) have been employed as a model cell in numerous studies of the porcine immune system. However, the lack of a standardized method for moM? differentiation hampers the comparison of results coming from the use of different laboratory…