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Pirbright reveals true cost of goat plague vaccination campaigns

A study led by The Pirbright Institute has created the first framework for determining the true cost of peste des petits ruminants (PPR) vaccine campaigns based on case studies in Ethiopia. PPR, also known as goat plague, is a contagious viral disease of sheep and goats…

Pirbright scientists share new protocol for creating vaccines that target multiple poultry diseases

Researchers at The Pirbright Institute have published their methods for creating a vaccine that protects against Marek’s disease and infectious bursal disease (IBD) using CRISPR/Cas9 gene editing system in the video journal JoVE. Both viruses cause highly infectious diseases…

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The genotype diversity within the H5N8 influenza A subtype

The H5N8 influenza subtype has been involved in the global spread of the Guangdong variant of the H5 hemagglutinin. The sequence data from all of the complete genomes from the H5N8 subtype was used to analyse the genotype diversity. Clustering analysis was used to assign…

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Review of epidemiological risk models for foot-and-mouth disease: Implications for prevention strategies with a focus on Africa

Foot-and-mouth disease (FMD) is a highly infectious transboundary disease that affects domestic and wild cloven-hoofed animal species. The aim of this review was to identify and critically assess some modelling techniques for FMD that are well supported by scientific…

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Neethling vaccine proved highly effective in controlling lumpy skin disease epidemics in the Balkans

Despite the wide use of the live attenuated Neethling lumpy skin disease (LSD) vaccine, only limited data existed on its efficacy and effectiveness prior to the large LSD epidemic in the Balkans, which took place during 2016–2017. In addition, analysis of risk factors for…

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Molecular characterization of peste des petits ruminants viruses in the Marmara Region of Turkey

Recent outbreaks of Peste des petits ruminants (PPR) in the Marmara region of Turkey including the European part of Thrace is important due to its proximity to Europe (Greece and Bulgaria) and the potential threat of spread of PPR into mainland Europe. In order to…

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Avian influenza A(H9N2) virus in poultry worker, Pakistan, 2015

Avian influenza A(H9N2) virus isolated from a poultry worker in Pakistan in 2015 was closely related to viruses detected in poultry farms. Observed mutations in the hemagglutinin related to receptor-binding affinity and antigenicity could affect cross-reactivity with…

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Pirbright student wins award to progress swine flu studies

Veronica Martini, first year PhD student in the Mucosal Immunology group at Pirbright, has received the In Vivo Skills Award from the Biotechnology and Biological Sciences Research Council ( BBSRC). The £17,600 funding will provide Veronica with the opportunity to learn new…

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Dissecting the genomic architecture of resistance to Eimeria maxima parasitism in the chicken

Coccidiosis in poultry, caused by protozoan parasites of the genus Eimeria, is an intestinal disease with substantial economic impact. With the use of anticoccidial drugs under public and political pressure, and the comparatively higher cost of live-attenuated vaccines, an…

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Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line

The re-emergence of poxviral zoonotic infections and the threat of bioterrorism emphasise the demand for effective antipoxvirus therapies. Here, we show that carbenoxolone, a pharmacological inhibitor of gap junction function and a compound widely used in cell culture, is…