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The SARS-CoV-2 spike protein has a broad tropism for mammalian ACE2 proteins

SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to SARS-CoV, as well as related coronaviruses…

default publication image

The SARS-CoV-2 spike protein has a broad tropism for mammalian ACE2 proteins

SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to SARS-CoV, as well as related coronaviruses…

default publication image

The SARS-CoV-2 spike protein has a broad tropism for mammalian ACE2 proteins

SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to SARS-CoV, as well as related coronaviruses…

default publication image

The SARS-CoV-2 spike protein has a broad tropism for mammalian ACE2 proteins

SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to SARS-CoV, as well as related coronaviruses…

COVID-19 testing equipment at The Pirbright Institute

Pirbright supports national test and trace programme

The Pirbright Institute will support the NHS Berkshire and Surrey Pathology Services (BSPS) and the national NHS Test and Trace programme by providing induction and training for staff joining the new Lighthouse Laboratory in Bracknell. The Lighthouse Laboratory is designed…

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Virus-like particle vaccines: A prospective panacea against an avian influenza panzootic

Epizootics of highly pathogenic avian influenza (HPAI) have resulted in the deaths of millions of birds leading to huge financial losses to the poultry industry worldwide. The roles of migratory wild birds in the harbouring, mutation, and transmission of avian influenza…

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Genomic diversity and evolution of quasi-species in Newcastle disease virus infections

Newcastle disease virus (NDV) infections are well known to harbour quasispecies, due to the error-prone nature of the RNA polymerase. Quasispecies variants in the fusion cleavage site of the virus are known to significantly change its virulence. However, little is known…

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Opinion: Standardizing the definition of gene drive

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Marek's disease virus (Gallid alphaherpesvirus 2)-encoded miR-M2-5p simultaneously promotes cell proliferation and suppresses apoptosis through RBM24 and MYOD1-mediated signaling pathways

MicroRNAs (miRNAs) have been demonstrated for their involvement in virus biology and pathogenesis, including functioning as key determinants of virally-induced cancers. As an important oncogenic α-herpesvirus affecting poultry health, Marek's disease virus serotype 1 […

A group of pigs

Pigs can still pass on swine flu infection after vaccination, Pirbright collaboration shows

Effective flu vaccines are crucial for controlling disease outbreaks in pigs and reducing the threat of transmission to humans. A collaboration between The Pirbright Institute, the Animal and Plant Health Agency (APHA), the University of Edinburgh and The Jenner Institute…