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Development and evaluation of molecular pen-side assays without prior RNA extraction for peste des petits ruminants (PPR) and foot and mouth disease (FMD)

Animal diseases such as peste des petits ruminants (PPR) and foot and mouth disease (FMD) cause significant economic losses in endemic countries and fast, accurate in-field diagnostics would assist with surveillance and outbreak control. The detection of these pathogens is…

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The first detection of a serotype O foot-and-mouth disease virus in Namibia

This report describes the molecular characterization of a serotype O foot-and-mouth disease virus (FMDV) recovered from a field outbreak in the Zambezi region, Namibia during July 2021. Sequence analysis demonstrates that this FMDV belongs to the O/EA-2 topotype sharing…

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How can vaccinating pigs protect people?

Many disease outbreaks, including Covid-19, are caused by viruses that have jumped from animals to humans. At the Pirbright Institute in the UK, Dr Rebecca McLean and Professor Simon Graham are studying one particular virus which did this in 1998 and continues to pose a…

New Chair of the Pirbright Trustee Board

The Pirbright Institute has announced the appointment of Professor Vince Emery as the Chair of the Trustee Board. This comes after the passing of Professor John Stephenson who served as Chair since April 2019. Professor Emery has been on the Pirbright Trustee Board for the…

Pirbright CEO Bryan Charleston with members of the VIDO collaboration

Pirbright continues to grow international collaborations to fight and prevent infectious disease

On 30 March 2022 Pirbright signed a memorandum of understanding (MOU) with the University of Saskatchewan’s Vaccine and Infectious Disease Organization (VIDO) in Canada. This exciting collaboration highlights the Institute’s global commitment to prevent and control…

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Identification and characterization of the 285L and K145R proteins of African swine fever virus

African swine fever (ASF) is a lethal disease of domestic pigs and wild boar, against which no vaccines are available to date. The large dsDNA genome of African swine fever virus (ASFV) contains up to 167 ORFs predicted to encode proteins. The functions and antigenic…

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Efficient transgene insertion in a pseudorabies virus vector by CRISPR/Cas9 and marker rescue-enforced recombination

For development of vectored vaccines against porcine pathogens the genome of the pseudorabies virus vaccine strain Bartha (PrV-Ba) was previously cloned as an infectious bacterial artificial chromosome (BAC), containing the bacterial replicon and a reporter gene cassette…

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Seroprevalence and Risk Factors for Exposure of Free-Range Poultry to Avian Influenza Viruses in Important Bird Areas in Uganda

Avian influenza (AI) viruses cause disease in domestic and wild bird species. Although these viruses have been reported to occur in poultry in Uganda, risk factors for their introduction and spread were largely unknown. We investigated the seroprevalence and risk factors for…

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Drivers and risk factors for circulating African swine fever virus in Uganda, 2012–2013

We explored observed risk factors and drivers of infection possibly associated with African swine fever (ASF) epidemiology in Uganda. Representative sub-populations of pig farms and statistics were used in a case-control model. Indiscriminate disposal of pig viscera and…

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Knowledge and perceptions of smallholder dairy farmers of cattle disease burdens in selected agro-ecological zones of Uganda

Diseases have continued to affect production and productivity in smallholder dairy farming systems in Uganda. This study sought to establish farmers knowledge and perceptions of disease burden in the Eastern Semi-Arid Zone (ESAZ), Lake Victoria Basin (LVB) and Western…