Search | The Pirbright Institute

Filters

default publication image

Fine mapping of the chicken salmonellosis resistance locus (SAL1)

Salmonella enterica serovar Typhimurium is a Gram-negative bacterium that has a significant impact on both human and animal health. It is one of the most common food-borne pathogens responsible for a self-limiting gastroenteritis in humans and a similar disease in pigs…

default publication image

Advances in dissecting mosquito innate immune responses to arbovirus infection

Arthropod-borne viruses - arboviruses - are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control arbovirus infections. In…

default publication image

Neurons and oligodendrocytes in the mouse brain differ in their ability to replicate Semliki Forest virus

Semliki Forest virus (SFV) provides an experimental model of acute virus encephalitis and virus-induced demyelinating disease. Two marker viruses expressing fluorescent proteins as part of the replicase or the structural open reading frame were used to evaluate virus…

default publication image

Effect of treatment with phytosterols in three herds with porcine respiratory disease complex

This case study includes three pig production systems belonging to two companies in Spain. Mortality, percent culls, average daily gain (ADG), and feed efficiency in Production Systems One and Two were incorporated into a database program and analyzed using statistical…

default publication image

Identification of chicken granulocyte colony-stimulating factor (G-CSF/CSF3): the previously described myelomonocytic growth factor is actually CSF3

The current chicken genome build contains only a single colony-stimulating factor (CSF) gene, granulocyte/macrophage (GM)-CSF (CSF2). However, genes encoding receptors for two other CSFs, G-CSF (CSF3) and M-CSF (CSF1), are present in the genome. Another apparently chicken…

default publication image

Phocine distemper virus in northern sea otters in the Pacific Ocean, Alaska, USA

Phocine distemper virus (PDV) has caused 2 epidemics in harbor seals in the Atlantic Ocean but had never been identified in any Pacific Ocean species. We found that northern sea otters in Alaska are infected with PDV, which has created a disease threat to several sympatric…

default publication image

Foot-and-mouth disease virus assembly: Processing of recombinant capsid precursor by exogenous protease induces self-assembly of pentamers in vitro in a myristoylation-dependent manner

The assembly of foot-and-mouth disease virus (FMDV) particles is poorly understood. In addition, there are important differences in the antigenic and receptor binding properties of virus assembly and dissociation intermediates, and these also remain unexplained. We have…

default publication image

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C

Human killer cell immunoglobulin-like receptors (KIRs) are distinguished by expansion of activating KIR2DS, whose ligands and functions remain poorly understood. The oldest, most prevalent KIR2DS is KIR2DS4, which is represented by a variable balance between "full-length"…

default publication image

Natural killer cell number and phenotype in bovine peripheral blood is influenced by age

Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of…

default publication image

Evolution and survival of marine carnivores did not require a diversity of killer Cell Ig-Like receptors or Ly49 NK cell receptors

Ly49 lectin-like receptors and killer cell Ig-like receptors (KIR) are structurally unrelated cell surface glycoproteins that evolved independently to function as diverse NK cell receptors for MHC class I molecules. Comparison of primates and various domesticated animals has…