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What is stopping the use of genetically modified insects for disease control?

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Characterization of foot-and-mouth disease viruses collected in Nigeria between 2007 and 2014: evidence for epidemiological links between West and East Africa

This study describes the molecular characterization of 47 foot-and-mouth disease (FMD) viruses recovered from field outbreaks in Nigeria between 2007 and 2014. Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2. Phylogenetic analyses of…

Promising results in search for a more efficient and effective vaccine against Marek’s disease

Scientists at The Pirbright Institute have been encouraged by the results from a potential new vaccine candidate against Marek’s disease (MD). Using a recombinant (new combinations of genetic material) adenovirus which carries a single gene from a virulent strain of Marek’s…

International conferences are “invaluable opportunities” for Pirbright students

Training is a key part of The Pirbright Institute’s mission and each year the Institute offers a diverse range of research projects for prospective PhD students. During their time at Pirbright, students would normally attend (and hopefully present at), at least one…

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SIT 2.0: 21st Century genetic technology for the screwworm sterile-insect program

Release of sterile insects, the Sterile Insect Technique (SIT), can be an extremely effective and precise method of pest control. A study in BMC Biology from the New World screwworm SIT program and others shows that modern genetic methods can provide major improvements even…

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Development and evaluation of tailored specific real-time RT-PCR assays for detection of foot-and-mouth disease virus serotypes circulating in East Africa

Rapid, reliable and accurate diagnostic methods provide essential support to programmes that monitor and control foot-and-mouth disease (FMD). While pan-specific molecular tests for FMD virus (FMDV) detection are well established and widely used in endemic and FMD-free…

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Replication defective adenovirus serotype 5 expressing Marek's disease virus envelope glycoprotein as a potential Marek's disease vaccine in chicken

The protective efficacy of a non-replicating Adenovirus serotype 5, expressing the immunogenic envelope glycoprotein B (Ad5-gB) of Mareks disease virus, was investigated in a vaccine-challenge model for Mareks disease in experimental chickens. In ovo vaccination with Ad5…

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Selection of reference genes for gene expression analysis by real-time qPCR in avian cells infected with infectious bronchitis virus

Infectious bronchitis virus (IBV) causes infectious bronchitis in poultry, a respiratory disease that is a source of major economic loss to the poultry industry. Detection and the study of the molecular pathogenesis of the virus often involves the use of real-time…

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Virus discovery using tick cell lines

While ticks have been known to harbor and transmit pathogenic arboviruses for over 80 years, the application of high-throughput sequencing technologies has revealed that ticks also appear to harbor a diverse range of endogenous tick-only viruses belonging to many different…

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Microscopic visualisation of zoonotic arbovirus replication in tick cell and organ cultures using Semliki Forest virus reporter systems

Ticks are vectors and reservoirs of many arboviruses pathogenic for humans or domestic animals; in addition, during bloodfeeding they can acquire and harbour pathogenic arboviruses normally transmitted by other arthropods such as mosquitoes. Tick cell and organ cultures…