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Dissecting the mechanism of intracellular Mycobacterium smegmatis growth inhibition by platelet activating factor C-16

Mycobacterium tuberculosis ( M.tb) infection results in approximately 1.3 million human deaths each year. M.tb resides primarily inside macrophages, and maintains persistent infection. In response to infection and inflammation, platelet activating factor C-16 (PAF C-16), a…

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Outbreak of African horse sickness in Thailand, 2020

African horse sickness was confirmed in horses in Thailand during March 2020. The virus was determined to belong to serotype 1 and is phylogenetically closely related to isolates from South Africa. This is the first incidence of African horse sickness occurring in Southeast…

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Limited cross-protection against infectious bronchitis provided by recombinant infectious bronchitis viruses expressing heterologous spike glycoproteins

Gammacoronavirus infectious bronchitis virus (IBV) causes an economically important respiratory disease of poultry. Protective immunity is associated with the major structural protein, spike (S) glycoprotein, which induces neutralising antibodies and defines the serotype…

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The evolution, spread and global threat of H6Nx avian influenza viruses

Avian influenza viruses of the subtype H6Nx are being detected globally with increasing frequency. Some H6Nx lineages are becoming enzootic in Asian poultry and sporadic incursions into European poultry are occurring more frequently. H6Nx viruses that contain mammalian…

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A ligation and restriction enzyme independent cloning technique: an alternative to conventional methods for cloning hard-to-clone gene segments in the influenza reverse genetics system

Background: Reverse genetics is used in many laboratories around the world and enables the creation of tailormade influenza viruses with a desired genotype or phenotype. However, the process is not flawless, and difficulties remain during cloning of influenza gene segments…

Trading poultry in a pakistani village

Science Spotlight: Hassaan Bin Aslam

Hassaan Bin Aslam, a veterinarian and microbiologist from Pakistan, is a student at The Pirbright Institute and the Royal Veterinary College whose project explores the structure of the Pakistan chicken industry to provide information that will aid scientists and policy…

Pig sniffing at apple

Pigs ideal for assessing flu antibody therapies, say Pirbright scientists

Studies undertaken at The Pirbright Institute in collaboration with Inovio Pharmaceuticals have shown that pigs can be used to assess whether influenza antibody therapies are effective, which could provide a better indication of their success in humans than small animal…

Transmission electron microscope image shows SARS-CoV-2, the virus that causes COVID-19. Crown-like spikes on the outer edge of the virus particles give coronaviruses their name.

SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19) which resulted in the human COVID-19 pandemic.

Transmission electron microscope image shows SARS-CoV-2, the virus that causes COVID-19. Crown-like spikes on the outer edge of the virus particles give coronaviruses their name.

SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19) which resulted in the human COVID-19 pandemic.

Transmission electron microscope image shows SARS-CoV-2, the virus that causes COVID-19. Crown-like spikes on the outer edge of the virus particles give coronaviruses their name.

SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19) which resulted in the human COVID-19 pandemic.