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Knighthood for Pirbright collaborator

Prof Sir Dave Stuart, the Director of Life Sciences at Diamond Light Source and MRC Professor of Structural Biology at the University of Oxford, and Head of the Division of Structural Biology at the Department of Clinical Medicine, has been awarded a Knighthood for his years…

Pupae of the wild-type and four different strains of genetically modified mosquitoes generated in the study. Different intensities of the green fluorescent marker indicate varying levels of the femaleless gene expression knockdown.

Mosquito gene discovery by Pirbright scientists could be harnessed to curb global malaria spread

A new gene that determines the sex of malaria mosquitoes has been discovered by scientists at The Pirbright Institute. The gene, named femaleless by the researchers, can be manipulated to prevent female mosquitoes from developing (only females bite to feed on blood and…

a blue graphic representation of the influenza virus

Latest Pirbright collaboration uncovers genetic markers that could guide avian influenza surveillance

Researchers at The Pirbright Institute have identified the genetic markers on avian influenza (‘bird flu’) viruses that could help the viruses to jump the species barrier and cause disease in people, in collaboration with other members of the One Health Poultry Hub. Co…

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Non-discriminatory exclusion testing as a tool for the early detection of foot-and-mouth disease incursions

Endemic circulation of foot-and-mouth disease (FMD) in Africa and Asia poses a continuous risk to countries in Europe, North America, and Oceania which are free from the disease. Introductions of the disease into a free region have dramatic economic impacts, especially if…

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Virus-encoded miR-155 ortholog in Marek's disease virus promotes cell proliferation via suppressing apoptosis by targeting tumor suppressor WWOX

Marek's disease virus serotype 1 (MDV-1) is an important oncogenic alpha-herpesvirus that induces immunosuppressive and rapid-onset T-cell lymphomatous disease in poultry commonly referred to as Marek's disease (MD). As an excellent biomodel for the study of virally-induced…

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The isolation and molecular characterization of an astrovirus from "yellow" chickens, China

Chicken astrovirus (CAstV) infection is strongly associated with kidney disease, gout, "white chicks" hatchery disease, and runting and stunting syndrome (RSS). In the present study, 82.5% of 154 clinical samples from different provinces in China were positive for CAstV by…

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Green synthesis as a simple and rapid route to protein modified magnetic nanoparticles for use in the development of a fluorometric molecularly imprinted polymer-based assay for detection of myoglobin

We have developed a low-cost molecularly imprinted polymer (MIP)-based fluorometric assay to directly quantify myoglobin in a biological sample. The assay uses a previously unreported method for the development of microwave-assisted rapid synthesis of aldehyde functionalized…

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Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles

Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in…

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Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza viruses

Receptor recognition and binding is the first step of viral infection and a key determinant of host specificity. The inability of avian influenza viruses to effectively bind human-like sialylated receptors is a major impediment to their efficient transmission in humans and…

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Targeting female flight for genetic control of mosquitoes

Aedes aegypti Act4 is a paralog of the Drosophila melanogaster indirect flight muscle actin gene Act88F. Act88F has been shown to be haploinsufficient for flight in both males and females (amorphic mutants are dominant). Whereas Act88F is expressed in indirect flight muscles…