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Infectious bronchitis virus (IBV): eLearning

Learn how to diagnose and control infectious bronchitis virus (IBV).

Photo of the front exterior of Pirbright's Jenner building. There are eight stone pillars. Blue sky with fluffy white clouds are see

Pirbright secures significant BBSRC investment to advance world-class research

The Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI), has announced a new portfolio of strategically important funding that will significantly enhance the UK’s capability to deliver world-leading research with socio…

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Heterogeneity of Phenotypic and Functional Changes to Porcine Monocyte-Derived Macrophages Triggered by Diverse Polarizing Factors In Vitro

Swine are attracting increasing attention as a biomedical model, due to many immunological similarities with humans. However, porcine macrophage polarization has not been extensively analyzed. Therefore, we investigated porcine monocyte-derived macrophages (moMΦ) triggered…

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Evaluating serological tests for foot-and-mouth disease while accounting for different serotypes and uncertain vaccination status

Controlling foot-and-mouth disease (FMD) by vaccination requires adequate population coverage and high vaccine efficacy under field conditions. To assure veterinary services that animals have acquired sufficient immunity, strategic post-vaccination surveys can be conducted…

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Complete genome analysis of African swine fever virus genotypes II, IX and XV from domestic pigs in Tanzania

African swine fever (ASF) caused by ASF virus (ASFV) is an infectious transboundary animal disease notifiable to the World Organization for Animal Health causing high mortality in domestic pigs and wild boars threatening the global domestic pig industry. To date, twenty-four…

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Pathological features of African horse sickness virus infection in IFNAR-/- mice

African Horse Sickness (AHS) is a vector-borne viral disease of equids. The disease can be highly lethal with mortality rates of up to 90% in non-immune equine populations. The clinical presentation in the equine host varies, but the pathogenesis underlying this variation…

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Chicken Glycogen Synthase Kinase 3β Suppresses Innate Immune Responses and Enhances Avian Leukosis Virus Replication in DF-1 Cells

Glycogen synthase kinase 3β (GSK3β) is a widely distributed multifunctional serine/threonine kinase. In mammals, GSK3β regulates important life activities such as proinflammatory response, anti-inflammatory response, immunity, and cancer development. However, the biological…

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ChAdOx1 nCoV-19 vaccination generates spike-specific CD8+ T cells in aged mice

Effective vaccines have reduced the morbidity and mortality caused by severe acute respiratory syndrome coronavirus-2 infection; however, the elderly remain the most at risk. Understanding how vaccines generate protective immunity and how these mechanisms change with age is…

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Efficient Cross-Screening and Characterization of Monoclonal Antibodies against Marek's Disease Specific Meq Oncoprotein Using CRISPR/Cas9-Gene-Edited Viruses

Marek's disease (MD) caused by pathogenic Marek's disease virus type 1 (MDV-1) is one of the most important neoplastic diseases of poultry. MDV-1-encoded unique Meq protein is the major oncoprotein and the availability of Meq-specific monoclonal antibodies (mAbs) is crucial…

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Effect of mucosal adjuvant IL-1β on heterotypic immunity in a pig influenza model

T cell responses directed against highly conserved viral proteins contribute to the clearance of the influenza virus and confer broadly cross-reactive and protective immune responses against a range of influenza viruses in mice and ferrets. We examined the protective…