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Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo

The possible emergence of drug-resistant avian flu raises concerns over the limited effectiveness of currently approved antivirals (neuraminidase inhibitors - NAIs) in the hypothetical event of a zoonotic spillover. Our study demonstrated that the recombinant avian A(H6N1)…

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African Swine Fever Virus Host-Pathogen Interactions

African swine fever virus is a complex double-stranded DNA virus that exhibits tropism for cells of the mononuclear phagocytic system. Virus replication is a multi-step process that involves the nucleus of the host cell as well the formation of large perinuclear sites where…

Culicoides biting midge feeding on blood

New seasonal control measures for bluetongue virus

Defra has announced a seasonally ‘vector low’ period when midge activity is much lower, leading to some changes to disease control measures for bluetongue virus (BTV-3). BTV-3 is the new strain of virus currently being found in northern Europe and UK. The virus is mainly…

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Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus

Introduction: Bluetongue virus (BTV) is an arthropod-borne Orbivirus that is almost solely transmitted by Culicoides biting midges and causes a globally important haemorrhagic disease, bluetongue (BT), in susceptible ruminants. Infection with BTV is characterised by…

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Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus

Introduction: Bluetongue virus (BTV) is an arthropod-borne Orbivirus that is almost solely transmitted by Culicoides biting midges and causes a globally important haemorrhagic disease, bluetongue (BT), in susceptible ruminants. Infection with BTV is characterised by…

default publication image

Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus

Introduction: Bluetongue virus (BTV) is an arthropod-borne Orbivirus that is almost solely transmitted by Culicoides biting midges and causes a globally important haemorrhagic disease, bluetongue (BT), in susceptible ruminants. Infection with BTV is characterised by…

default publication image

Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus

Introduction: Bluetongue virus (BTV) is an arthropod-borne Orbivirus that is almost solely transmitted by Culicoides biting midges and causes a globally important haemorrhagic disease, bluetongue (BT), in susceptible ruminants. Infection with BTV is characterised by…

Two very young Rhode Island Red chicks

Avian bronchitis vaccine replicates in cell culture

Researchers at The Pirbright Institute have found it is possible to generate novel vaccines for avian bronchitis that are capable of replicating in cell culture. Writing in the journal PLOS One, the team outline how a virus generated using reverse genetics was found to offer…

Group of five people from Pirbright in a line smiling in front of a large white poster. One is holding a certificate.

Pirbright celebrates Athena Swan Silver Award

The quest for gender equality at The Pirbright Institute has been recognised through an Athena Swan Silver Award. The Athena Swan Charter is a framework used across the globe to support and transform gender equality within higher education (HE) and research. The five-year…

A person in a fluorescent orange jacket pointing at electrical parts on the left with two people on the right in jackets smiling

Pirbright drives energy efficiencies

The Pirbright Institute is cutting fossil fuel energy use and costs across its Surrey campus in 2024. The Institute analysed the energy efficiency of its buildings and infrastructure in 2022-23 to develop a site-wide energy plan that drives down gas and electricity…