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Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds

In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing…

Leading Pirbright scientist honoured by US science association

The American Association for the Advancement of Science (AAAS) has selected a senior scientist at The Pirbright Institute as a 2017-2018 AAAS Alan I. Leshner Leadership Institute Public Engagement Fellow. Dr Anthony Wilson, Group Leader for Integrative Entomology (the study…

Pirbright Professor receives prestigious joint Royal Society Award

Professor Venugopal Nair OBE, Head of the Avian Viral Diseases programme at The Pirbright Institute, has been jointly awarded the prestigious Royal Society International Collaboration Award for Research Professors. This new award was established by the Society to foster and…

Improved genetic database an “invaluable resource” for global disease research

The growing popularity and use of free access scientific databases, is crucial to research into animal and human diseases, say researchers from The Pirbright Institute, who help manage one such database, working in partnership with scientists from the blood cancer charity…

The Pirbright Institute chooses a Bull supercomputer

A new Bull supercomputer delivered to The Pirbright Institute by Atos, will boost the Institute’s capability to carry out bioinformatic analysis of animal virus diseases for research and surveillance purposes, say its senior scientists. High-Performance Computing (HPC) and…

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Avian Influenza projects

Research projects Current projects Grant Title Value BB/T013087/1 Development of next generation vaccine technology inducing rapid and strong immunity through targeted delivery of antigens to chicken immune cells £473,080 BB/R50595X/1 Enhancing protective efficacy of avian…

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GM technology unlocks potential for new generation of poultry vaccines

Scientists at The Pirbright Institute have used genetic engineering to develop a more efficient and effective vaccine for Marek’s disease which could pave the way for a new generation of poultry disease vaccines. International poultry production has tripled over the last 20…

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Re-emergence of peste des petits ruminants virus in 2015 in Morocco: molecular characterization and experimental infection in Alpine goats

Peste des Petits Ruminants (PPR) is a transboundary viral disease of small ruminants that causes huge economic losses in Africa, The Middle East and Asia. In Morocco, the first PPR outbreak was notified in 2008. Since then no cases were reported for seven years, probably due…

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Development of a novel real-time RT-PCR assay to detect Seneca Valley virus associated with emerging cases of vesicular disease in pigs

Seneca Valley virus (SVV) can cause vesicular disease that is clinically indistinguishable from foot-and-mouth disease, vesicular stomatitis and swine vesicular disease. SVV-associated disease has been identified in pigs in several countries, namely USA, Canada, Brazil and…

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Avian leukosis virus subgroup J induces VEGF expression via NF-kappaB/PI3K-dependent IL-6 production

Avian leukosis virus subgroup J (ALV-J) is an oncogenic virus causing hemangiomas and myeloid tumors in chickens. Interleukin-6 (IL-6) is a multifunctional pro-inflammatory interleukin involved in many types of cancer. We previously demonstrated that IL-6 expression was…