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Pirbright CEO Bryan Charleston with members of the VIDO collaboration

Pirbright continues to grow international collaborations to fight and prevent infectious disease

On 30 March 2022 Pirbright signed a memorandum of understanding (MOU) with the University of Saskatchewan’s Vaccine and Infectious Disease Organization (VIDO) in Canada. This exciting collaboration highlights the Institute’s global commitment to prevent and control…

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Identification and characterization of the 285L and K145R proteins of African swine fever virus

African swine fever (ASF) is a lethal disease of domestic pigs and wild boar, against which no vaccines are available to date. The large dsDNA genome of African swine fever virus (ASFV) contains up to 167 ORFs predicted to encode proteins. The functions and antigenic…

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Efficient transgene insertion in a pseudorabies virus vector by CRISPR/Cas9 and marker rescue-enforced recombination

For development of vectored vaccines against porcine pathogens the genome of the pseudorabies virus vaccine strain Bartha (PrV-Ba) was previously cloned as an infectious bacterial artificial chromosome (BAC), containing the bacterial replicon and a reporter gene cassette…

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Seroprevalence and Risk Factors for Exposure of Free-Range Poultry to Avian Influenza Viruses in Important Bird Areas in Uganda

Avian influenza (AI) viruses cause disease in domestic and wild bird species. Although these viruses have been reported to occur in poultry in Uganda, risk factors for their introduction and spread were largely unknown. We investigated the seroprevalence and risk factors for…

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Drivers and risk factors for circulating African swine fever virus in Uganda, 2012–2013

We explored observed risk factors and drivers of infection possibly associated with African swine fever (ASF) epidemiology in Uganda. Representative sub-populations of pig farms and statistics were used in a case-control model. Indiscriminate disposal of pig viscera and…

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Knowledge and perceptions of smallholder dairy farmers of cattle disease burdens in selected agro-ecological zones of Uganda

Diseases have continued to affect production and productivity in smallholder dairy farming systems in Uganda. This study sought to establish farmers knowledge and perceptions of disease burden in the Eastern Semi-Arid Zone (ESAZ), Lake Victoria Basin (LVB) and Western…

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Efficacy of a modified live virus vaccine against porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) administered to 1-day-old piglets in front of heterologous PRRSV-1 challenge

PRRSV is one of the most important viruses in the global swine industry and is often controlled by the use of modified live virus (MLV) vaccines. This study assessed the impact of a PRRSV-1 MLV vaccine applied to 1-day-old piglets challenged on day 28 of life with a PRRSV-1…

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Local and systemic T cell immunity in fighting pig viral and bacterial infections

T cells are an essential component of the adaptive immune system. Over the last 15 years, a constantly growing toolbox with which to study T cell biology in pigs has allowed detailed investigations on these cells in various viral and bacterial infections. This review…

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TMT-based proteomic analysis reveals integrins involved in the synergistic infection of reticuloendotheliosis virus and avian leukosis virus subgroup J

BACKGROUND: Co-infection with the avian leukosis virus subgroup J (ALV-J) and the reticuloendotheliosis virus (REV) increases mutual viral replication, causing a more serious pathogenic effect by accelerating the progression of neoplasia and extending the tumor spectrum…

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Costs and benefits of mutational robustness in RNA viruses

The accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of…