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Research paper

A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong

Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that is currently spreading throughout Asia. The disease situation is of high importance for farmers and policy makers in Asia. In October 2020, feral cattle in Hong Kong developed multi-focal…
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Research paper

A recombinant turkey herpesvirus expressing the F protein of Newcastle disease virus genotype XII generated by NHEJ-CRISPR/Cas9 and Cre-LoxP systems confers protection against genotype XII challenge in chickens

In this study, we developed a new recombinant virus rHVT-F using a Turkey herpesvirus (HVT) vector, expressing the fusion (F) protein of the genotype XII Newcastle disease virus (NDV) circulating in Peru. We evaluated the viral shedding and efficacy against the NDV genotype…
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Research paper

CRISPR/Cas9 editing of duck enteritis virus genome for the construction of a recombinant vaccine vector expressing omph gene of Pasteurella multocida in two novel insertion sites

Duck enteritis virus (DEV) and Pasteurella multocida, the causative agent of duck plague and fowl cholera, are acute contagious diseases and leading causes of morbidity and mortality in duck. The NHEJ-CRISPR/Cas9-mediated gene editing strategy, accompanied with the Cre–Lox…
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Research paper

Identification of diffusion routes of O/EA-3 topotype of foot-and-mouth disease virus in Africa and Western Asia between 1974 and 2019 - a phylogeographic analysis

Foot-and-mouth disease (FMD) affects the livestock industry and socio-economic sustainability of many African countries. The success of FMD control programs in Africa depends largely on understanding the dynamics of FMD virus (FMDV) spread. In light of the recent outbreaks…
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Research paper

A systematic review of the methods used to analyse the economic impact of endemic foot-and-mouth disease

Foot-and-mouth disease (FMD) has large economic consequences in livestock systems, which must be robustly assessed to support disease control policy. This study described and assessed methods used within economic analyses of FMD and its control in endemic contexts. A…
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Research paper

A systematic review of the methods used to analyse the economic impact of endemic foot-and-mouth disease

Foot-and-mouth disease (FMD) has large economic consequences in livestock systems, which must be robustly assessed to support disease control policy. This study described and assessed methods used within economic analyses of FMD and its control in endemic contexts. A…
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Research paper

Development and evaluation of molecular pen-side assays without prior RNA extraction for peste des petits ruminants (PPR) and foot and mouth disease (FMD)

Animal diseases such as peste des petits ruminants (PPR) and foot and mouth disease (FMD) cause significant economic losses in endemic countries and fast, accurate in-field diagnostics would assist with surveillance and outbreak control. The detection of these pathogens is…
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Research paper

The first detection of a serotype O foot-and-mouth disease virus in Namibia

This report describes the molecular characterization of a serotype O foot-and-mouth disease virus (FMDV) recovered from a field outbreak in the Zambezi region, Namibia during July 2021. Sequence analysis demonstrates that this FMDV belongs to the O/EA-2 topotype sharing…
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Research paper

How can vaccinating pigs protect people?

Many disease outbreaks, including Covid-19, are caused by viruses that have jumped from animals to humans. At the Pirbright Institute in the UK, Dr Rebecca McLean and Professor Simon Graham are studying one particular virus which did this in 1998 and continues to pose a…
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Article

New Chair of the Pirbright Trustee Board

The Pirbright Institute has announced the appointment of Professor Vince Emery as the Chair of the Trustee Board. This comes after the passing of Professor John Stephenson who served as Chair since April 2019. Professor Emery has been on the Pirbright Trustee Board for the…
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