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RNA binding as an emerging regulatory dimension in the type I IFN response

The type I interferon (IFN-I) response shapes the intracellular environment to suppress virus infection. Historically, this remodeling has been linked to the transcriptional induction of interferon-stimulated genes (ISGs). However, IFN-I-driven post-translational regulation…

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Whole genome analysis of selection associated with resistance to heat stress in chickens

Following their domestication, chickens were translocated around the world to novel environments. Through a combination of natural and artificial selection, chickens adapted to these local conditions, creating significant genetic diversity across populations worldwide…

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Clues about coronavirus replication in host cells uncovered by Pirbright scientists

More clues about coronavirus replication in humans and animals have been uncovered by researchers at Pirbright. This research fills in important knowledge gaps that could help to control disease caused by a range of coronaviruses in the future. When we think of coronaviruses…

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Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope

Abstract Foot-and-mouth disease virus (FMDV) causes a devastating disease that threatens global food security. Vaccination is hindered by antigenic diversity across serotypes. To identify cross-serotype neutralising epitopes, we isolated 24 FMDV-specific antibodies from…

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Characterization of African swine fever outbreaks in Hong Kong SAR, winter 2023 to 2024

Abstract Hong Kong veterinary authorities responded to a series of suspected outbreaks of African swine fever in domestic pigs in the New Territories of the Hong Kong Special Administrative Region from November 2023 to January 2024. Cases were identified on 10 farms, with…

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New research from Pirbright reveals how Marek’s disease may directly affect the chicken immune system

Marek’s disease virus (MDV) causes disease in chickens and is estimated to cost the global poultry industry up to US $2 billion each year. In the early stages of disease, the virus has a direct effect on the chicken’s immune system and prevents it functioning correctly…

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Efficacy of a novel antigen-decorated adenoviral vaccine platform against porcine respiratory coronavirus infection in a large natural host

Porcine respiratory coronavirus (PRCV) infection in pigs provides a physiologically and immunologically relevant large-animal model for acute respiratory coronavirus disease and vaccine evaluation. We investigated a replication-defective adenovirus (Ad) vaccine platform that…

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Postinfection Pig and Ferret Antisera Show Similar Antigenic Profiles for Human Influenza A(H1N1pdm09) Viruses

ABSTRACT Background Monitoring antigenic drift in human influenza A viruses is essential for vaccine strain selection and ensuring protection against circulating strains. Antigenic drift is traditionally assessed using ferret antisera, which provide monospecific responses…

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Researchers at Pirbright investigate the emergence of new bird flu viruses with the potential to infect people

Pirbright scientists have discovered that infection with two strains of avian flu can lead to the emergence of a new virus strain with the potential to jump from birds to humans. Human cases of avian influenza are extremely rare but can occur if a person comes into very…

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Absence of a dose–response relationship after intra-oropharyngeal inoculation of pigs with foot-and-mouth disease virus serotype O

Abstract Foot-and-mouth disease virus (FMDV) poses significant economic threats to livestock industries worldwide, with its serotype O being the most prevalent globally and responsible for all outbreaks in Europe in the last 25 years. This retrospective multi-centre study…