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Pexophagy-driven redox imbalance promotes virus-induced ferroptosis

Peroxisomes are critical organelles that maintain cellular redox homeostasis. Many viruses induce oxidative stress and degrade peroxisomes, but the mechanisms and consequences remain unclear. In this study, we systematically investigate how virus-induced pexophagy regulates…

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Swine influenza A virus infection sets the local immunological landscape in subsequent infection with porcine reproductive and respiratory syndrome virus

Farmed pigs are frequently exposed to respiratory infections, with swine influenza A virus (swIAV) and porcine reproductive and respiratory syndrome virus (PRRSV) being key drivers. Most co-infection studies with these viruses have focused on PRRSV infection followed by…

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Exploiting Viral DNA Genomes to Explore the Dispersal History of African Swine Fever Genotype II Lineages in Europe.

African swine fever virus (ASFV) is a highly virulent DNA virus that causes African swine fever, a severe hemorrhagic disease affecting domestic and wild pigs, leading to significant animal health burdens and economic losses. Initially limited to the sub-Saharan African…

An empty CL3 laboratory at The Pirbright Institute. There are three Biological safety cabinets, two of which have yellow gloves that go into the cabinet

Launch of the Biorisk Advisor Training course

A new training course developed at The Pirbright Institute has been approved by the Royal Society of Biology (RSB) for continuing professional development (CPD) purposes. This approval recognises and underscores its relevance and value to those in the field and marks a…

Very large and close group of cattle in India. They all have horns

Scientists pioneer ‘early warning’ analysis for foot-and-mouth disease

A novel lineage of foot-and-mouth disease virus (FMDV) can have severe socio-economic impacts in Asia. Researchers at the FAO World Reference Laboratory for FMD (WRLFMD), based at The Pirbright Institute, have tracked an emerging FMDV lineage in the Middle East. Writing in…

Cattle being herded

Tools to assess the performance of FMD vaccines – driving improvements in quality

Despite widespread use of inactivated vaccines to control foot-and-mouth disease (FMD), there is no systematic approach to demonstrate the regional relevance of products against the specific serotypes and strains that circulate in endemic countries in Africa and Asia. A…

A Chef and a person stood on grass together looking at the camera. Behind them on the left is a green cylinder with metal legs. White words on the green composter read "ridan food waste composter. keeping the world turning."

Mulch ado about food waste

A new composter is helping The Pirbright Institute recycle its food waste, fertilise allotments and reduce its carbon footprint. The hot aerobic composter uses no power and blends wood pellets with canteen waste to produce up to 6.5 tonnes of mulch a year on site. For every…

Small herd of white cattle in South Africa on dried grass. The image has a sunset haze to it.

Pirbright expertise informs economic analysis for foot-and-mouth disease control

How much should policymakers invest in controlling animal diseases that spread across national borders, who should pay, and will intervention really work? A researcher at The Pirbright Institute is one of a team of seven authors who have drafted a new handbook for the Food…

Small young yellow chick on sawdust. Both legs have little loose yellow rings

Pirbright’s openness on animal research rewarded

The Pirbright Institute’s commitment to openness on animal research has been rewarded with continued recognition from Understanding Animal Research (UAR). The three-year reaccreditation of the Institute as a Leader in Openness to 2028 marks the third renewal of the award for…

This scanning electron microscope image shows SARS-CoV-2 (yellow)—also known as 2019-nCoV, the virus that causes COVID-19—isolated from a patient in the U.S., emerging from the surface of cells (pink) cultured in the lab.

Pirbright in £10m collaboration to fight animal and plant disease

The Pirbright Institute has joined a £10m advanced technology surveillance programme to strengthen the UK’s biosecurity and protect animals, plants, people and trade. Advanced genome sequencing technologies - a method that reads the complete genetic code of a living organism…