Search | The Pirbright Institute

Filters

default publication image

Coding-complete genome sequence of an African swine fever virus strain Liv13/33 isolate from experimental transmission between pigs and Ornithodoros moubata ticks

Here, we report the coding-complete genome sequence of African swine fever (ASF) virus strain Liv13/33, isolated from experimentally infected pigs and Ornithodoros moubata ticks. The 11 sequences that we obtained harbored no notable differences to each other, and all of them…

default publication image

Discrete virus factories form in the cytoplasm of cells co-infected with two replication competent tagged reporter birnaviruses, that subsequently coalesce over time

The Birnaviridae family, responsible for major economic losses to poultry and aquaculture, are non-enveloped viruses with a segmented double-stranded (ds)RNA genome that replicate in discrete cytoplasmic virus factories (VFs). Reassortment is common, however, the underlying…

default publication image

Avian Herpesviruses

Avian herpesviruses (AHV) are an important group of pathogens affecting a most species of domestic, wild and captive birds. With a large DNA genome that shows some degree of structural conservation, AHV encode a number of structural and non-structural proteins that are…

default publication image

Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages

Infectious diseases are typically studied in isolation, but in real life people often encounter multiple infections simultaneously. Here we investigate how the innate immune response to the fatal fungus Cryptococcus neoformans is influenced by viral coinfection. Whilst…

Flourescence image of rinderpest

Genetic analysis of rinderpest by Pirbright scientists reveals new information

Scientists at The Pirbright Institute have shed new light on the genetics, evolution and spread of rinderpest by analysing the genetic sequences of the stocks destroyed at the Rinderpest Holding Facility and World Reference Laboratory for rinderpest held at Pirbright. In…

default publication image

Molecular characterization and phylogenetic analysis of Marek’s disease virus in Turkish layer chickens

1. There is no current data about the genotypes of Marek's disease virus (MDV) in Turkish poultry flocks, hence, this study was performed to analyse CVI988/Rispens, turkey herpesvirus (HVT) vaccine viruses and MDV field viruses as well as to perform phylogenetic analysis of…

default publication image

Molecular characterization and phylogenetic analysis of Marek’s disease virus in Turkish layer chickens

1. There is no current data about the genotypes of Marek's disease virus (MDV) in Turkish poultry flocks, hence, this study was performed to analyse CVI988/Rispens, turkey herpesvirus (HVT) vaccine viruses and MDV field viruses as well as to perform phylogenetic analysis of…

default publication image

Identification and characterization of the vasa gene in the diamondback moth, Plutella xylostella

Vasa is an ATP-dependent RNA helicase, participating in multiple biological processes. It has been widely used as a germ cell marker and its promoter has become a key component of several genetic pest control systems. Here we present the vasa gene structure and its promoter…

default publication image

RNAseq reveals of the contribution of interferon stimulated genes to the increased host defense and decreased PPR viral replication in cattle.

Peste des petits ruminants virus (PPRV) is known to replicate in a wide variety of ruminants causing very species-specific clinical symptoms. Small ruminants (goats and sheep) are susceptible to disease while domesticated cattle and buffalo are dead-end hosts and do not…

default publication image

Lumpy skin disease is characterized by severe multifocal dermatitis with necrotizing fibrinoid vasculitis following experimental infection

Lumpy skin disease is a high-consequence disease in cattle caused by infection with the poxvirus lumpy skin disease virus (LSDV). The virus is endemic in most countries in Africa and an emerging threat to cattle populations in Europe and Asia. As LSDV spreads into new…