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Marek's disease virus (Gallid alphaherpesvirus 2)-encoded miR-M2-5p simultaneously promotes cell proliferation and suppresses apoptosis through RBM24 and MYOD1-mediated signaling pathways

MicroRNAs (miRNAs) have been demonstrated for their involvement in virus biology and pathogenesis, including functioning as key determinants of virally-induced cancers. As an important oncogenic α-herpesvirus affecting poultry health, Marek's disease virus serotype 1 […

A group of pigs

Pigs can still pass on swine flu infection after vaccination, Pirbright collaboration shows

Effective flu vaccines are crucial for controlling disease outbreaks in pigs and reducing the threat of transmission to humans. A collaboration between The Pirbright Institute, the Animal and Plant Health Agency (APHA), the University of Edinburgh and The Jenner Institute…

aedes aegypti female mosquito feeding

Flightless female mosquitoes generated at Pirbright could aid disease control

Scientists at The Pirbright Institute have created flightless mosquitoes by editing a specific gene that is required for flight – but only in females. This could provide a more controlled and targeted way of reducing mosquito populations (females bite to obtain a blood meal…

Young chicken looks at the camera side on.

Pirbright scientists reveal more clues on how bird flu viruses evade vaccine immunity

A new study by researchers at The Pirbright Institute shows that avian influenza viruses can combine two techniques to evade vaccine immunity, aiding their spread in the field. Understanding the dynamics between these methods could allow researchers to develop better…

Dr Yaoyao Zhang at CN Bio using the Physiomimix technology

Science Spotlight: Bringing home new technologies

After four weeks of intensive training, Dr Yaoyao Zhang departed CN Bio Innovations, a Cambridge-based bioengineering company, ready to incorporate new technology and skills into her own research at The Pirbright Institute. Dr Zhang’s training involved learning how CN Bio’s…

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Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness

Influenza viruses have an error-prone polymerase complex that facilitates a mutagenic environment. Antigenic mutants swiftly arise from this environment with the capacity to persist in both humans and economically important livestock even in the face of vaccination…

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Patterns of RNA editing in Newcastle disease virus infections

The expression of accessory non-structural proteins V and W in Newcastle disease virus (NDV) infections depends on RNA editing. These proteins are derived from frameshifts of the sequence coding for the P protein via co-transcriptional insertion of one or two guanines in the…

IBV strain M41-CK (red) growing in Vero cells (green with blue nuclei) in the presence of trypsin

Pirbright reveals new method to study poultry virus (IBV) which could reduce the need to use birds in research

An enzyme called trypsin boosts the growth of infectious bronchitis virus (IBV) strains in lab cell cultures, scientists at The Pirbright Institute have shown. This finding could enable researchers to study strains of the poultry virus that were previously inaccessible and…

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Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion

Although enveloped viruses canonically mediate particle entry through virus-cell fusion, certain viruses can spread by cell-cell fusion, brought about by receptor engagement and triggering of membrane-bound, viral-encoded fusion proteins on the surface of cells. The…

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Distribution of droplets and immune responses after aerosol and intra-nasal delivery of influenza virus to the respiratory tract of pigs

Recent evidence indicates that local immune responses and tissue resident memory T cells (TRM) are critical for protection against respiratory infections but there is little information on the contributions of upper and lower respiratory tract (URT and LRT) immunity. To…