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Autophagy impairment by African swine fever virus

African swine fever is a devastating disease of domestic swine and wild boar caused by a large double-stranded DNA virus that encodes for more than 150 open reading frames. There is no licensed vaccine for the disease and the most promising current candidates are modified…

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The emerging role of perivascular cells (pericytes) in viral pathogenesis

Viruses may exploit the cardiovascular system to facilitate transmission or within-host dissemination, and the symptoms of many viral diseases stem at least in part from a loss of vascular integrity. The microvascular architecture is comprised of an endothelial cell barrier…

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Analysis of the avian coronavirus spike protein reveals heterogeneity in the glycans present

Infectious bronchitis virus (IBV) is an economically important coronavirus, causing damaging losses to the poultry industry worldwide as the causative agent of infectious bronchitis. The coronavirus spike (S) glycoprotein is a large type I membrane protein protruding from…

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Household and animal factors associated with sheeppox and goatpox sero-prevalence and identification of high-risk areas in selected States of northern Nigeria

Sheeppox and goatpox (SGP) are transboundary, highly contagious diseases affecting sheep and goats with characteristic clinical signs. SGP affect populations of small ruminants in Africa, Asia and the Middle East and, as a result, threaten farmers’ livelihoods. Despite their…

A herd of water buffalo in Asia graze on grass at the water's edge

Lumpy skin disease: tackling an epidemic in the midst of a pandemic

While the COVID-19 pandemic continues to dominate media reports, and African swine fever (ASF) occupies the farming trade publications, a third disease, unknown to many, is spreading at pace across the globe. Lumpy skin disease (LSD) is a devastating disease of cattle and…

Securing our future: the value of veterinary vaccines, IVNN and BSI report cover

Veterinary vaccinology report sets out key recommendations to ensure future readiness for disease threats

Today the British Society for Immunology (BSI) and the International Veterinary Vaccinology Network (IVVN) have published 'Securing our future: the value of veterinary vaccines'. The joint report lays out the current veterinary vaccinology landscape, identifies threats to…

Newcastle disease virus bioimage

Newcastle disease (ND): eLearning

Learn about Newcastle disease virus, how it spreads and clinical signs.

A map showing the spread of foot-and-mouth disease virus variants across Asia

Pirbright study identifies risk factors that drive FMD outbreaks in Asia

https://www.youtube.com/watch?v=KYOC83wA3DA An international project led by scientists in the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD) at The Pirbright Institute has tracked the evolution of FMD virus (FMDV) over nearly 20 years to reveal how different…

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nsP4 is a major determinant of alphavirus replicase activity and template selectivity

Alphaviruses have positive-strand RNA genomes containing two open reading frames (ORFs). The first ORF encodes the non-structural (ns) polyproteins P123 and P1234 that act as precursors for the subunits of the viral RNA replicase (nsP1-nsP4). Processing of P1234 leads to the…

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Development of nanobodies targeting peste des petits ruminants virus: the prospect in disease diagnosis and therapy

Peste des petits ruminants virus (PPRV) causes a highly devastating disease, peste des petits ruminants (PPR) of sheep and goats, that threatens food security, small ruminant production, and the conservation of wild small ruminants in many developing countries, especially in…