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Funding strengthens Pirbright and Glasgow Centre for Virus Research partnership

The long-term partnership between The Pirbright Institute and MRC-University of Glasgow Centre for Virus Research (CVR) has been strengthened by a joint funding award of £500,000 from the Biotechnology and Biological Sciences Research Council (BBSRC). Pirbright and the CVR…

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Complete genome sequencing of field isolates of peste des petits ruminants virus from Tanzania revealed a high nucleotide identity with lineage III PPR viruses

Peste des petits ruminants virus (PPRV) causes a highly devastating disease of sheep and goats that threatens food security, small ruminant production and susceptible endangered wild ruminants. With policy directed towards achieving global PPR eradication, the establishment…

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Development of a novel loop mediated isothermal amplification assay (LAMP) for the rapid detection of epizootic haemorrhagic disease virus

Epizootic haemorragic disease (EHD) is an important disease of white-tailed deer and can cause a bluetongue-like illness in cattle. A definitive diagnosis of EHD relies on molecular assays such as real-time RT-qPCR or conventional PCR. Reverse transcription loop-mediated…

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Characterization of foot-and-mouth disease viruses in Zambia - implications for the epidemiology of the disease in Southern Africa

The livestock industry supports livelihood and nutritional security of at least 42% of people in the Southern African Development Community region. However, presence of animal diseases such as foot-and-mouth disease poses a major threat to the development of this industry…

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Stability of chimpanzee adenovirus vectored vaccines (ChAdOx1 and ChAdOx2) in liquid and lyophilised formulations

Adenovirus vectored vaccines have entered global use during the COVID-19 pandemic, and are in development for multiple other human and veterinary applications. An attraction of the technology is the suitability of the vaccines for storage at 2- 8 °C for months. Widely used…

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Presence of antibodies to SARS-CoV-2 in domestic cats in Istanbul, Turkey, before and after COVID-19 pandemic

Recent studies demonstrated that domestic cats can be naturally and experimentally infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study was performed to investigate the presence of SARS-CoV-2-specific antibodies within the domestic cat…

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Emergence of West Nile virus lineage-2 in resident corvids in Istanbul, Turkey

West Nile fever is a vector-borne viral disease affecting animals and humans causing significant health and economic problems globally. This study was aimed at investigating circulating West Nile virus (WNV) strains in free-ranging corvids in Istanbul, Turkey. Brain, liver…

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Production of recombinant replication-defective lentiviruses bearing the SARS-CoV or SARS-CoV-2 attachment Spike glycoprotein and their application in receptor tropism and neutralisation assays

For enveloped viruses, such as SARS-CoV-2, transmission relies on the binding of viral glycoproteins to cellular receptors. Conventionally, this process is recapitulated in the lab by infection of cells with isolated live virus. However, such studies can be restricted due to…

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Amino acid substitutions in the H5N1 avian influenza haemagglutinin alter pH of fusion and receptor binding to promote a highly pathogenic phenotype in chickens

Highly pathogenic H5N1 avian influenza viruses cause devastating outbreaks in farmed poultry with serious consequences for animal welfare and economic losses. Zoonotic infection of humans through close contact with H5N1 infected birds is often severe and fatal. England…

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Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection

Murine norovirus (MNV) is widely used as a model for studying norovirus biology. While MNV isolates vary in their pathogenesis, infection of immunocompetent mice mostly results in persistent infection. The ability of a virus to establish a persistent infection is dependent…