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Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors

Cattle possess three IgG subclasses. However, the key immune functions, including complement and NK cell activation, and enhancement of phagocytosis, are not fully described for bovine IgG1, 2 and 3. We produced chimeric monoclonal antibodies (mAbs) consisting of a defined…

Heard of African buffalo in long grass with one looking directly at the camera

Veterinary Vaccine Centre welcomed in White Paper

The expertise of the Centre for Veterinary Vaccine Innovation and Manufacturing (CVIM) at The Pirbright Institute has been recognised in a Government White Paper aimed at ending world hunger. CVIM is celebrating its first year as a scientifically independent centre for…

Marek's disease virus vaccine

Laboratory diagnosis of Marek’s disease (MD): Instructor-led

Learn about Marek's disease and diagnostics.

Professor Bryan Charleston and Peter Stoicheff shakes hands, with Dr. Volker Gerdts stood behind them.

Pirbright and VIDO expands collaboration to advance vaccine manufacturing

The Centre for Veterinary Vaccine Innovation and Manufacturing (CVIM) at The Pirbright Institute has signed a memorandum of understanding (MOU) with The University of Saskatchewan’s (USask) Vaccine and Infectious Disease Organization (VIDO). The MOU allows for expanded…

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Visualisation of bluetongue virus in the salivary apparatus of Culicoides biting midges highlights the accessory glands as a primary arboviral infection site

Arthropods transmit a wide range of pathogens of importance for the global health of humans, animals, and plants. One of these arthropod vectors, Culicoides biting midges (Diptera: Ceratopogonidae), are the biological vectors of several human and animal pathogens, including…

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Creating resistance to avian influenza infection through genome editing of the ANP32 gene family

Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene edited (GE) chickens containing two ANP32A amino acid substitutions that…

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A primer on correlation-based dimension reduction methods for multi-omics analysis

The continuing advances of omic technologies mean that it is now more tangible to measure the numerous features collectively reflecting the molecular properties of a sample. When multiple omic methods are used, statistical and computational approaches can exploit these large…

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A primer on correlation-based dimension reduction methods for multi-omics analysis

The continuing advances of omic technologies mean that it is now more tangible to measure the numerous features collectively reflecting the molecular properties of a sample. When multiple omic methods are used, statistical and computational approaches can exploit these large…

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Capsid-Specific Antibody Responses of Domestic Pigs Immunized with Low-Virulent African Swine Fever Virus

African swine fever (ASF) is a lethal disease in pigs that has grave socio-economic implications worldwide. For the development of vaccines against the African swine fever virus (ASFV), immunogenic antigens that generate protective immune responses need to be identified…

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Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti

Multiple viruses, including pathogenic viruses, bacteriophages, and even plant viruses, cause a phenomenon termed superinfection exclusion whereby a currently infected cell is resistant to secondary infection by the same or a closely related virus. In alphaviruses, this…