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The Pirbright Institute statement on Black Lives Matter

Racism takes many different forms, but whether open, insidious or structural, it can take lives and breeds hate. The Pirbright Institute condemns racism and recognises the importance of taking a stand with our employees and the wider research community who are voicing their…

Herd of black and brown cows in a field facing directly toward the camera

Pirbright case study shows pooled milk can be used for foot-and-mouth disease surveillance

A case study undertaken by scientists at The Pirbright Institute is the first to confirm that milk obtained from in-line milk samplers on a large-scale dairy farm can be used to detect circulating foot-and-mouth disease virus (FMDV) in cattle. Previous work carried out by…

Herd of black and brown cows in a field facing directly toward the camera

Pirbright case study shows pooled milk can be used for foot-and-mouth disease surveillance

A case study undertaken by scientists at The Pirbright Institute is the first to confirm that milk obtained from in-line milk samplers on a large-scale dairy farm can be used to detect circulating foot-and-mouth disease virus (FMDV) in cattle. Previous work carried out by…

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A vaccine-matching assessment of different genetic variants of serotype O foot-and-mouth disease virus isolated in Ethiopia between 2011 and 2014

The aim of this study was to assess the vaccine-matching and antigenic properties of foot-and-mouth disease virus (FMDV) isolates collected from Ethiopia between 2011 and 2014. Samples (n = 51) were collected from cattle and pigs with clinical signs consistent with foot-and…

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Absence of long-term protection in domestic pigs immunized with attenuated African swine fever virus isolate OURT88/3 or BeninDeltaMFG correlates with increased levels of regulatory T cells and IL-10

Following short immunization protocols, naturally attenuated African swine fever virus (ASFV) isolate OURT88/3 and deletion mutant BeninΔMGF have previously been shown to induce high percentage of protection in domestic pigs against challenge with virulent virus. Results…

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A single shot pre-fusion-stabilized bovine RSV F vaccine is safe and effective in newborn calves with maternally derived antibodies

Achieving safe and protective vaccination against respiratory syncytial virus (RSV) in infants and in calves has proven a challenging task. The design of recombinant antigens with a conformation close to their native form in virus particles is a major breakthrough. We…

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Identification and RNAi profile of a novel iflavirus infecting Senegalese Aedes vexans arabiensis mosquitoes

The inland floodwater mosquito Aedes vexans (Meigen, 1830) is a competent vector of numerous arthropod-borne viruses such as Rift Valley fever virus ( Phenuiviridae) and Zika virus ( Flaviviridae). Aedes vexans spp. have widespread Afrotropical distribution and are common…

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Truncation of PA-X contributes to virulence and transmission of H3N8 and H3N2 canine influenza viruses in dogs

Equine-origin H3N8 and avian-origin H3N2 canine influenza viruses (CIVs) prevalent in dogs are thought to pose a public health threat arising from intimate contact between dogs and humans. However, our understanding of CIV virulence is still limited. Influenza A virus PA-X…

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Risk factors for outbreaks of lumpy skin disease and the economic impact in cattle farms of Nakuru County, Kenya

Lumpy Skin Disease (LSD) is an emerging disease of cattle that causes substantial economic loss to affected regions. However, factors favouring transmission under field conditions and farm-level impacts are poorly quantified. This was a retrospective case-control study of…

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A pool of eight virally vectored African swine fever antigens protect pigs against fatal disease

Classical approaches to African swine fever virus (ASFV) vaccine development have not been successful; inactivated virus does not provide protection and use of live attenuated viruses generated by passage in tissue culture had a poor safety profile. Current African swine…