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Identification of a functional small non-coding RNA encoded by African swine fever virus

African swine fever virus (ASFV) causes a lethal haemorrhagic disease of domestic pigs, against which there is no vaccine available. ASFV has a large, double-stranded DNA genome that encodes over 150 proteins. Replication takes place predominantly in the cytoplasm of the…

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Quantifying the transmission of foot-and-mouth disease virus in cattle via a contaminated environment

Indirect transmission via a contaminated environment can occur for a number of pathogens, even those typically thought of as being directly transmitted, such as influenza virus, norovirus, bovine tuberculosis, or foot-and-mouth disease virus (FMDV). Indirect transmission…

Human bronchial epithelial cells with staining for RSV protein (green), NFKB p65 (red) and DNA (blue).

Pirbright discovers respiratory virus steals proteins to halt antiviral response

Viruses have evolved many ways to avoid detection by the immune system. A recent study by scientists at The Pirbright Institute has revealed that both bovine and human respiratory syncytial viruses (bRSV and hRSV respectively) capture a protein that is important for the…

Human bronchial epithelial cells with staining for RSV protein (green), NFKB p65 (red) and DNA (blue).

Pirbright discovers respiratory virus steals proteins to halt antiviral response

Viruses have evolved many ways to avoid detection by the immune system. A recent study by scientists at The Pirbright Institute has revealed that both bovine and human respiratory syncytial viruses (bRSV and hRSV respectively) capture a protein that is important for the…

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Identification of Newcastle disease virus subgenotype VII.2 in wild birds in Turkey

Background: Newcastle disease viruses (NDVs) can spread across continents via migratory birds. Hence, we investigated the frequency of NDV in both non-migratory and birds migrating on the Black Sea-Mediterranean flyway, in Istanbul, Turkey. Birds were trapped using nets…

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The characterisation of chIFITMs in avian coronavirus infection in vivo, ex vivo and in vitro

The coronaviruses are a large family of enveloped RNA viruses that commonly cause gastrointestinal or respiratory illnesses in the infected host. Avian coronavirus infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of chickens that can affect the…

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The characterisation of chIFITMs in avian coronavirus infection in vivo, ex vivo and in vitro

The coronaviruses are a large family of enveloped RNA viruses that commonly cause gastrointestinal or respiratory illnesses in the infected host. Avian coronavirus infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of chickens that can affect the…

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Avian leukosis virus subgroup J induces B cell anergy mediated by Lyn inhibited BCR signal transduction

Immune tolerance induced by avian leukosis virus subgroup J (ALV-J) is a prerequisite for tumorigenesis. Although we had reported that B cell anergy induced by ALV-J was the main reason for immune tolerance, the molecular mechanism still remains unclear. Here, we found SU…

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Towards a sampling rationale for African swine fever virus detection in pork products

African swine fever (ASF) is a highly lethal disease of pigs caused by the ASF virus (ASFV), which presents a serious threat to global food security. The movement of contaminated pork products has previously been postulated as contributing to the introduction of ASF into new…

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Towards a sampling rationale for African swine fever virus detection in pork products

African swine fever (ASF) is a highly lethal disease of pigs caused by the ASF virus (ASFV), which presents a serious threat to global food security. The movement of contaminated pork products has previously been postulated as contributing to the introduction of ASF into new…