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Nipah virus induced cell-cell fusion leads to the formation of fluorescent syncytia shown in green (multi-nucleated cells) in Pirbright’s mFIT assay

Pirbright test detects antibodies that block viruses from causing cell fusion, including SARS-CoV-2

A new test developed by researchers at The Pirbright Institute, in collaboration with the University of Queensland and the University of Oxford, can detect antibodies that prevent cell-to-cell fusion, a method some viruses use to infect neighbouring cells. The new test is a…

pigs in a field

Pirbright partners with ECO Animal Health and The Vaccine Group to develop new PRRS vaccines

The Pirbright Institute will undertake two projects with ECO Animal Health Group plc (ECO) to develop vaccine candidates for porcine respiratory and reproductive syndrome virus (PRRSV). The first project is a tripartite collaboration between The Pirbright Institute, The…

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Federation of European Laboratory Animal Science Associations recommendations of best practices for the health management of ruminants and pigs used for scientific and educational purposes

Most ruminants and pigs used for scientific and educational aims are bred not for these purposes but in a farm environment. Given the wide range of diseases that these species might have, ensuring that the animals’ health status is appropriate can be complex and challenging…

Dr Don King, head of Vesicular Disease Reference Laboratories at The Pirbright Institute

Science Spotlight: Dr Don King

https://www.youtube.com/watch?v=-dWnWLH7qO0 In a world where COVID-19 has dominated the news media and redirected the attention of many scientific endeavours, it is worth remembering that there are still many other diseases which are continuously monitored to control and…

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Thapsigargin at non-cytotoxic levels induces a potent host antiviral response that blocks influenza A virus replication

Influenza A virus is a major global pathogen of humans, and there is an unmet need for effective antivirals. Current antivirals against influenza A virus directly target the virus and are vulnerable to mutational resistance. Harnessing an effective host antiviral response is…

Cells infected with African swine fever

African swine fever (ASF): eLearning

Learn the essentials of African swine fever detection and control with our eLearning course, designed for vets and laboratory professionals.

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Ommochrome pathway genes kynurenine 3-hydroxylase and cardinal participate in eye pigmentation in Plutella xylostella

Eye pigmentation genes have been utilized as visible markers for constructing genetic control prototypes in several insect vectors of human disease. Here, orthologs of two ommochrome pathway genes, kynurenine 3-hydroxylase (kmo) and cardinal, were investigated in Plutella…

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Changes to virus taxonomy and the Statutes ratified by the International Committee on Taxonomy of Viruses (2020)

This article reports the changes to virus classification and taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in March 2020. The entire ICTV was invited to vote on 206 taxonomic proposals approved by the ICTV Executive Committee at…

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Genetic biocontrol for invasive species

Invasive species are increasingly affecting agriculture, food, fisheries, and forestry resources throughout the world. As a result of global trade, invasive species are often introduced into new environments where they become established and cause harm to human health…

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Quantifying and modelling the acquisition and retention of lumpy skin disease virus by haematophagus insects reveals clinically but not subclinically-affected cattle are promoters of viral transmission and key targets for control of disease outbreaks

Lumpy skin disease virus (LSDV), is a vector-transmitted poxvirus that causes disease in cattle. The vector species involved in LSDV transmission and their ability to acquire and transmit the virus are poorly characterised. Using a highly representative bovine experimental…