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A systematic evaluation of high-throughput sequencing approaches to identify low-frequency variants in viral populations

High-throughput sequencing such as those provided by Illumina are an efficient way to understand sequence variation within viral populations. However, challenges exist in distinguishing process-introduced error from biological variance, which significantly impacts our…

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A systematic evaluation of high-throughput sequencing approaches to identify low-frequency variants in viral populations

High-throughput sequencing such as those provided by Illumina are an efficient way to understand sequence variation within viral populations. However, challenges exist in distinguishing process-introduced error from biological variance, which significantly impacts our…

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Identification of a newly conserved SLA-II epitope in a structural protein of swine influenza virus

Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have…

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Towards a unified generic framework to define and observe contacts between livestock and wildlife: a systematic review

Wild animals are the source of many pathogens of livestock and humans. Concerns about the potential transmission of economically important and zoonotic diseases from wildlife have led to increased surveillance at the livestock-wildlife interface. Knowledge of the types…

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Towards a unified generic framework to define and observe contacts between livestock and wildlife: a systematic review

Wild animals are the source of many pathogens of livestock and humans. Concerns about the potential transmission of economically important and zoonotic diseases from wildlife have led to increased surveillance at the livestock-wildlife interface. Knowledge of the types…

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Simultaneous detection of bluetongue virus serotypes using xMAP technology

Bluetongue is an economically important disease of ruminants caused by the bluetongue virus (BTV). BTV is serologically diverse, which complicates vaccination strategies. Rapid identification of the causative BTV serotypes is critical, however, real-time PCR (RT-qPCR) can be…

Cholesterol (blue) and MDV glycoprotein B (green) in infected cells in the presence of a cholesterol inhibitor. Nuclei shown in white.

Interrupting cholesterol pathway reduces Marek’s disease spread, Pirbright study shows

In a new discovery, scientists from The Pirbright Institute confirm that cholesterol production and transport play a crucial role in how Marek’s disease virus (MDV) infects poultry cells. Researchers also found that inhibiting a protein involved in this pathway can reduce…

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Antiviral effect of baicalin on Marek’s disease virus in CEF cells

Background: Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti…

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A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. The vaccine is based on the display of coronavirus spike glycoprotein receptor-binding domain…

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A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. The vaccine is based on the display of coronavirus spike glycoprotein receptor-binding domain…