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Unpicking the secrets of African swine fever viral replication sites

African swine fever virus (ASFV) is a highly contagious pathogen which causes a lethal haemorrhagic fever in domestic pigs and wild boar. The large, double-stranded DNA virus replicates in perinuclear cytoplasmic replication sites known as viral factories. These factories…

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Thermal limits for flight activity of field-collected Culicoides in the United Kingdom defined under laboratory conditions

BACKGROUND: Culicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of internationally important arboviruses and inflict biting nuisance on humans, companion animals and livestock. In temperate regions, transmission of arboviruses is limited by temperature…

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Thermal limits for flight activity of field-collected Culicoides in the United Kingdom defined under laboratory conditions

BACKGROUND: Culicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of internationally important arboviruses and inflict biting nuisance on humans, companion animals and livestock. In temperate regions, transmission of arboviruses is limited by temperature…

default publication image

Thermal limits for flight activity of field-collected Culicoides in the United Kingdom defined under laboratory conditions

BACKGROUND: Culicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of internationally important arboviruses and inflict biting nuisance on humans, companion animals and livestock. In temperate regions, transmission of arboviruses is limited by temperature…

African swine fever virus factory showing virus particles forming in red.

Stunning images allow Pirbright scientists to unpick the secrets of African swine fever viral replication

Transmission electron microscope image of a viral factory showing new virions amongst dense protein/membrane accumulationsDeveloping effective vaccines and treatments against African swine fever virus (ASFV), which kills up to 100 percent of the pigs it infects, has been…

African swine fever virus factory showing virus particles forming in red.

Stunning images allow Pirbright scientists to unpick the secrets of African swine fever viral replication

Transmission electron microscope image of a viral factory showing new virions amongst dense protein/membrane accumulationsDeveloping effective vaccines and treatments against African swine fever virus (ASFV), which kills up to 100 percent of the pigs it infects, has been…

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Depletion of CD8+ T cells from vaccinated goats does not affect protection from challenge with wild type peste des petits ruminants virus

Peste des petits ruminants (PPR) is a severe disease of goats and sheep that is widespread in Africa, the Middle East and Asia. The disease is caused by peste des petits ruminants virus (PPRV); cell culture‐attenuated strains of PPRV have been shown, both experimentally and…

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High-dimensional CyTOF analysis of dengue virus-infected human DCs reveals distinct viral signatures

Dengue virus (DENV) is the most prevalent mosquito-borne virus causing human disease. Of the 4 DENV serotypes, epidemiological data suggest that DENV-2 secondary infections are associated with more severe disease than DENV-4 infections. Mass cytometry by time-of-flight…

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Characterization of the Zika virus induced small RNA response in Aedes aegypti cells

RNA interference (RNAi) controls arbovirus infections in mosquitoes. Two different RNAi pathways are involved in antiviral responses: the PIWI-interacting RNA (piRNA) and exogenous short interfering RNA (exo-siRNA) pathways, which are characterized by the production of virus…

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Virion incorporation of the Herpes simplex virus type 1 tegument protein VP22 occurs via glycoprotein E-specific recruitment to the late secretory pathway

The mechanism by which herpesviruses acquire their tegument is not yet clear. One model is that outer tegument proteins are recruited by the cytoplasmic tails of viral glycoproteins. In the case of herpes simplex virus tegument protein VP22, interactions with the…