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A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles are coloured red, the rest of the cell image is purple.

Zika virus

Zika virus (ZIKV) is primarily transmitted by mosquitoes in tropical and subtropical regions.

A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles are coloured red, the rest of the cell image is purple.

Zika virus

Zika virus (ZIKV) is primarily transmitted by mosquitoes in tropical and subtropical regions.

Dengue virus electron microscopy image

Dengue virus

Dengue virus (DENV), present predominantly in tropical regions, is primarily transmitted to humans by infected mosquitoes.

Dengue virus electron microscopy image

Dengue virus

Dengue virus (DENV), present predominantly in tropical regions, is primarily transmitted to humans by infected mosquitoes.

Glass model of foot-and-mouth-disease virus (FMDV), lit in purple

Pirbright welcomes three scientific experts to head up new areas of research

Three new research groups have been established at The Pirbright Institute recently, each of which will contribute to the Institute’s mission to prevent and control viral diseases of livestock and viruses that spread from animals to people, known as zoonoses. Discover more…

Glass model of foot-and-mouth-disease virus (FMDV), lit in purple

Pirbright welcomes three scientific experts to head up new areas of research

Three new research groups have been established at The Pirbright Institute recently, each of which will contribute to the Institute’s mission to prevent and control viral diseases of livestock and viruses that spread from animals to people, known as zoonoses. Discover more…

Glass model of foot-and-mouth-disease virus (FMDV), lit in purple

Pirbright welcomes three scientific experts to head up new areas of research

Three new research groups have been established at The Pirbright Institute recently, each of which will contribute to the Institute’s mission to prevent and control viral diseases of livestock and viruses that spread from animals to people, known as zoonoses. Discover more…

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The flavivirus polymerase NS5 regulates translation of viral genomic RNA

Flaviviruses, including dengue virus and Zika virus, contain a single-stranded positive sense RNA genome that encodes viral proteins essential for replication and also serves as the template for new genome synthesis. As these processes move in opposite directions along the…

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Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c

Knockout mouse models have been extensively used to study the antiviral activity of IFIT (interferon-induced protein with tetratricopeptide repeats). Human IFIT1 binds to cap0 (m7GpppN) RNA, which lacks methylation on the first and second cap-proximal nucleotides (cap1…

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Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells

Background: Norovirus, also known as the winter vomiting bug, is the predominant cause of non-bacterial gastroenteritis worldwide. Disease control is predicated on a robust innate immune response during the early stages of infection. Double-stranded RNA intermediates…