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Impact of specific N-glycan modifications on the use of plant-produced SARS-CoV-2 antigens in serological assays

The receptor binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in the virus-host cell interaction, and viral infection. The RBD is a major target for neutralizing antibodies, whilst recombinant RBD is commonly used as an antigen in serological assays…

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Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens

Maternally derived antibodies (MDAs) are important for protecting chickens against pathogens in the neonatal stage however, they often interfere with vaccine performance. Here, we investigated the effects of MDAs on a targeted antigen delivery vaccine (TADV), which is…

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Isolation, identification, and genomic characterization of chicken astrovirus isolates from China

Chicken astrovirus (CAstV) infection can cause diarrhea, nephritis, stunted growth, and “white chickens” condition, resulting in economic losses to the poultry industry. Currently, a few CAstVs were isolated and a few full-length genome sequences of CAstV have been deposited…

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Evaluation of electropolymerized molecularly imprinted polymers (E-MIPs) on disposable electrodes for detection of SARS-CoV-2 in saliva

We investigate electropolymerized molecularly imprinted polymers (E-MIPs) for the selective recognition of SARS-CoV-2 whole virus. E-MIPs imprinted with SARS-CoV-2 pseudoparticles (pps) were electrochemically deposited onto screen printed electrodes by reductive…

Coloured image of SARS-CoV-2 viruses

SARS-CoV-2 variants can infect a wider range of animal cells according to new research led by Pirbright

SARS-CoV-2, the virus that causes COVID-19, can potentially infect a wider number of animal species including rodents and ferrets, reveal Pirbright scientists. The study found that SARS-CoV-2 variants Alpha, Beta and Delta can infect more species compared to the ancestral…

brown chickens with red combs

Research reveals even more benefits associated with the new bird flu vaccine developed at Pirbright

Pirbright scientists recently developed a potential bird flu vaccine that offered better protection to chickens. This vaccine was easier and less costly to produce than traditional flu vaccines. Researchers at the Institute have now discovered even more benefits from this…

Image of a cell infected with Mareks disease

Pirbright discovers ways to improve vaccine development and control of Marek’s disease virus

Research by Pirbright scientists reveals that the chicken immune response to Marek’s disease virus (MDV) differs depending on the genetic makeup of infected birds, with some chickens being more resistant to disease than others. MDV is a highly contagious virus that affects…

The inside of The Philip Mellor Insectary (PMI) at The Pirbright Institute

Science spotlight: Day in the life breeding insects in the Pirbright Philip Mellor Insectary

Dr Melanie Nicholls is a postdoctoral scientist at The Pirbright Institute working in the Philip Mellor Insectary (PMI), a specialist science facility which houses exotic and endemic (native to the UK) insects for use in research on vector-borne viruses. Six bio secure…

Disease Detectives

Have you got what it takes to become a Disease Detective? Pandemic preparedness: why scientists are key Discover how emerging diseases are spread and how research helps to prevent and contain them. Scientists play a critical role in identifying, controlling and preventing…

Flock of brown and white chickens following a person in boots

Pirbright develops new ways to create safe vaccines to protect poultry from infectious bronchitis virus

Researchers from The Pirbright Institute working to improve vaccines for infectious bronchitis virus (IBV) have identified targets in the virus’s genetic code that could make vaccines safer. Better vaccines would have a huge impact on improving health and welfare of poultry…