Research paper Criteria for identifying and evaluating candidate sites for open-field trials of genetically engineered mosquitoes Recent laboratory successes in the development of genetically engineered mosquitoes for controlling pathogen transmission have fostered the need for standardized procedures for advancing the technical achievements to practical tools. It is incumbent in many cases for the… Read more
Research paper Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion Although neoplasia is a major cause of mortality in humans and domestic animals, it has rarely been described in wildlife species. One of the few examples is a highly prevalent urogenital carcinoma in California sea lions (CSLs). Although the aetiology of this carcinoma is… Read more
Research paper Morbillivirus vaccines: recent successes and future hopes The impact of morbilliviruses on both human and animal populations is well documented in the history of mankind. Indeed, prior to the development of vaccines for these diseases, morbilliviruses plagued both humans and their livestock that were heavily relied upon for food… Read more
Research paper Recombinant vaccines against bluetongue virus Bluetongue (BT) is a hemorrhagic disease of ruminants caused by bluetongue virus (BTV), the prototype member of the genus Orbivirus within the family Reoviridae and is transmitted via biting midges of the genus Culicoides. BTV can be found on all continents except Antarctica… Read more
Research paper Vaccination of mice with a modified Vaccinia Ankara (MVA) virus expressing the African horse sickness virus (AHSV) capsid protein VP2 induces virus neutralising antibodies that confer protection against AHSV upon passive immunisation In previous studies we showed that a recombinant Modified Vaccinia Ankara (MVA) virus expressing the protein VP2 of AHSV serotype 4 (MVA-VP2) induced virus neutralising antibodies in horses and protected interferon alpha receptor gene knock-out mice (IFNAR?/?) against… Read more
Research paper Virus and host factors affecting the clinical outcome of bluetongue virus infection Bluetongue is a major infectious disease of ruminants caused by bluetongue virus (BTV), an arbovirus transmitted by Culicoides. Here, we assessed virus and host factors influencing the clinical outcome of BTV infection using a single experimental framework. We investigated… Read more
Research paper Bluetongue, Schmallenberg virus ... African horse sickness? Following the incursions into the UK of bluetongue virus (BTV) in 2007 and Schmallenberg virus (SBV) in 2011, an increasingly pertinent question for those tasked with predicting and responding to outbreaks of livestock arboviruses in the UK is, what is next? Culicoides, the… Read more
Research paper Patterns of foot-and-mouth disease virus distribution in Africa: the role of livestock and wildlife in virus emergence Foot-and-mouth disease (FMD) is one of the most highly contagious diseases of animals. The disease is distributed on three continents (Asia, Africa and South America) where it disrupts the food security of people who depend on livestock and animal products. Substantial… Read more
Basic page Foot-and-mouth disease diagnostic reagents Bovine control serum, rabbit and guinea pig sera, inactivated antigens, NSP panel, ELISA kits, monoclonal antibodies. Read more
Research paper Expansion of anti-mesothelin specific CD4(+) and CD8(+) T cell responses in patients with pancreatic carcinoma We aimed to assess the status of naturally occurring CD4(+) and CD8(+) T cell responses to a tumour associated antigen, Mesothelin, in patients with pancreatic carcinoma and study the effects of elevated IL-10 on Mesothelin-specific T cell responses. For that sake, short… Read more
