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Recombinant vaccines against infectious bronchitis

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Modification of the avian coronavirus infectious bronchitis virus for vaccine development

Infectious bronchitis virus (IBV) causes an infectious respiratory disease of domestic fowl that affects poultry of all ages causing economic problems for the poultry industry worldwide. Although IBV is controlled using live attenuated and inactivated vaccines it continues…

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Epigenetic regulation of the latency-associated region of Marek's disease virus in tumor-derived T-cell lines and primary lymphoma

Meq is the major Marek's disease virus (MDV)-encoded oncoprotein and is essential for T-cell lymphomagenesis. Meq and several noncoding RNAs, including three microRNA (MiR) clusters, are expressed from the repeats of the MDV genome during latent infection of T cells. To…

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A novel approach to generating morbillivirus vaccines: negatively marking the rinderpest vaccine

The eradication of rinderpest virus (RPV) from the globe was possible through the availability of a safe and effective live attenuated vaccine and a suitable companion diagnostic test. However, the inability to serologically 'Differentiate between naturally Infected and…

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The presence and possible effects of bluetongue virus in goat herds in Israel

In spite of the many reports on bluetongue (BT) in cattle and sheep, publications on BT-attributed manifestations in goats naturally infected with bluetong-ue virus (BTV) are scarce, and up to now there have been no reports on BT-attributed manifestations in goats in Israel…

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Adenovirus expressing human interferon inhibits replication of foot and mouth disease virus and reduces fatal rate in mice

Interferon is an important cytokine that plays a critical role in the initial host defense against viral infection. Recombinant human adenoviruses expressing human interferon-? (Ad-HIFN?) or pig interferon-? fused with interleukin-18 (Ad-PIFN?-IL18) were constructed and used…

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Eimeria species parasites as novel vaccine delivery vectors: anti-Campylobacter jejuni protective immunity induced by Eimeria tenella-delivered CjaA

Vaccination of poultry against coccidiosis caused by the Eimeria species is almost entirely based upon varied formulations of live parasites. The recent development of a series of protocols that support genetic complementation by transfection in Eimeria now provides an…

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Constraints on haplotype structure and variable gene frequencies suggest a functional hierarchy within cattle MHC class I

Six major histocompatibility complex (MHC) classical class I genes have been identified in cattle, and up to three of these are expressed in variable combinations on different haplotypes. The origin and functional significance of this genetic complexity is unknown. However…

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Selective forces shaping diversity in the class I region of the major histocompatibility complex in dairy cattle

The major histocompatibility complex (MHC) is one of the most diverse regions of the mammalian genome. Diversity in MHC genes is integral to their function in the immune system, and while pathogens play a key role in shaping this diversity, the contribution of other…

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The tomato genome sequence provides insights into fleshy fruit evolution

Tomato (Solanum lycopersicum) is a major crop plant and a model system for fruit development. Solanum is one of the largest angiosperm genera(1) and includes annual and perennial plants from diverse habitats. Here we present a high-quality genome sequence of domesticated…