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Direct amplification and sequencing of enterovirus genomes from clinical and wastewater samples reveals uncommon virus types in Cameroon

Knowledge about the genetic diversity of enteroviruses in sub-Saharan Africa remains biased by the fact that it has mainly been described through the characterization of specimens isolated in cell cultures. The aim of this study was to characterize enteroviruses that…

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Foot-and-Mouth Disease Vaccines by Design; Production of Capsid-Modified Foot-and-Mouth Disease Viruses with Improved Cell Culture Growth

Background/objectives: Vaccination is important for controlling foot-and-mouth disease (FMD) in endemic regions and to lessen the effects of outbreaks in FMD-free countries. The adaptation of FMD virus to BHK cells is a necessary but time-consuming and costly step in vaccine…

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Porcine respiratory coronavirus as a model for acute respiratory disease: mechanisms of different infection outcomes

Porcine respiratory coronavirus (PRCV) is a naturally occurring pneumotropic coronavirus in the pig, providing a valuable large animal model to study acute respiratory disease. PRCV pathogenesis and the resulting immune response were investigated in pigs, the natural large…

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SARS-CoV-2 variants retain high airborne transmissibility by different strategies

SARS-CoV-2 variants evolve to balance immune evasion and airborne transmission, yet the mechanisms remain unclear. In hamsters, first-wave, Alpha, and Delta variants transmitted efficiently via aerosols. Alpha emitted fewer viral particles than first-wave virus but…

Close up of two pink pigs lying on straw

Pigs provide insights into coronavirus-induced lung damage

Respiratory viruses are a major threat to global health, but why some people experience severe lung damage from infections like SARS-CoV-2 while others have mild symptoms is something that researchers have sought to understand. A new study lead by Pirbright researchers uses…

Group of six pink pigs on straw

Animal trials underway in quest for African swine fever vaccine

A vaccine candidate for African swine fever (ASF) is undergoing tests at The Pirbright Institute. Developed in partnership between the Institute and The Vaccine Group (TVG), the candidate is being clinically trialled in vaccinated pigs. “Vaccinated pigs will be challenged…

Seven people in a row wearing reflective jackets and hardhats. Laura Dance in the middle is holding a shovel. Behind the group are orange construction vehicles

Groundbreaking celebrates start of CVIM construction

A groundbreaking ceremony has celebrated the first major milestone in the delivery of the Centre for Veterinary Vaccine Innovation and Manufacturing (CVIM). Laura Dance, newly-appointed Chief Operating Officer of the UKRI Biotechnology and Biological Sciences Research…

A group of pigs

Lung memory cell study can aid vaccine development

Understanding how cell memory is induced and maintained helps scientists to study immunity and design more effective, long-lasting vaccines. In a collaborative study, researchers from The Pirbright Institute, the Institute for Infection & Immunity, City St George’s…

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Distribution of aminopeptidase N coronavirus receptors in the respiratory and digestive tracts of domestic and wild artiodactyls and carnivores

Aminopeptidase N (APN) is a transmembrane protein that mediates the attachment of the spike protein of several clinically important coronaviruses (CoVs) responsible for respiratory and intestinal diseases in animals and humans. To assess the potential for APN-mediated viral…

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Distribution of aminopeptidase N coronavirus receptors in the respiratory and digestive tracts of domestic and wild artiodactyls and carnivores

Aminopeptidase N (APN) is a transmembrane protein that mediates the attachment of the spike protein of several clinically important coronaviruses (CoVs) responsible for respiratory and intestinal diseases in animals and humans. To assess the potential for APN-mediated viral…