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Poultry health course flies back after five years

A week-long poultry health course for vets, technical staff and poultry managers is being relaunched after a five-year break. Designed and taught by specialists at The Pirbright Institute, University of Surrey, and UK industry experts, the course combines hands-on practicals…

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Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR is counteracted by the upregulation of growth arrest and DNA damage…

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Metabolomics analysis of CEF cells infected with avian leukosis virus subgroup J based on UHPLC-QE-MS

Avian leukosis virus subgroup J (ALV-J) is a retrovirus that can cause immunosuppression and tumors in chicken. However, relative pathogenesis is still not clear. At present, metabolomics has shown great potential in the screening of tumor metabolic markers, prognostic…

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MentforMe

Connecting individuals across institutes to advance careers through tailored, innovative mentoring experiences.

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Transcription termination and readthrough in African swine fever virus

African swine fever virus (ASFV) is a nucleocytoplasmic large DNA virus (NCLDV) that encodes its own host-like RNA polymerase (RNAP) and factors required to produce mature mRNA. The formation of accurate mRNA 3′ ends by ASFV RNAP depends on transcription termination, likely…

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African swine fever virus NAM P1/95 is a mixture of genotype I and genotype VIII viruses

African swine fever virus causes a lethal hemorrhagic disease of domestic pigs. The NAM P1/1995 isolate was originally described as B646L genotype XVIII; however, full genome sequencing revealed that this assignment was incorrect.

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DEFEND celebrates five years of success

A global scientific consortium which set out to control two major livestock virus epidemics in Europe is celebrating five years of research findings. Coordinated and led by The Pirbright Institute, and funded through the European Union’s Horizon 2020 innovation and research…

Advancing African swine fever virus (ASFV) vaccines

In an effort to combat the devastating impact of African swine fever (ASF) on global food security, Pirbright researchers have secured funding from the Medical Research Council to assess the cross-protection potential of modified live vaccines (MLV) against diverse ASF virus…

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Full genome sequence analysis of African swine fever virus isolates from Cameroon

African swine fever (ASF) is a devastating disease of domestic pigs that has spread across the globe since its introduction into Georgia in 2007. The etiological agent is a large double-stranded DNA virus with a genome of 170 to 180 kb in length depending on the isolate…