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Evaluation of the immunogenicity of an mRNA vectored Nipah virus vaccine candidate in pigs

Nipah virus (NiV) poses a significant threat to human and livestock populations across South and Southeast Asia. Vaccines are required to reduce the risk and impact of spillover infection events. Pigs can act as an intermediate amplifying host for NiV and, separately…

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An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution

Throughout the COVID-19 pandemic, SARS-CoV-2 variants have been designated as variants of concern (VOCs) and variants of interest (VOIs) on the basis of their potential to replace previously circulating variants and cause new waves of increased transmission globally; such…

nipah virus

Consortium in quest for ‘single shot’ bivalent Nipah virus vaccine

An international consortium of scientists and commercial partners is aiming to develop a vaccine and companion diagnostic test for Nipah virus (NiV). The newly emerging zoonotic disease infects pigs and can spread to people. Carried by fruit bats, it can cause human…

Pioneering partnership to improve swine health

The Pirbright Institute is partnering with researchers at The Vaccine Group (TVG) in Plymouth on a new project that sets out to control African swine fever (ASF). Pirbright researchers are collaborating with TVG to accelerate the development of safe and effective vaccines…

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MAIT cell-MR1 reactivity is highly conserved across multiple divergent species

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize small molecule metabolites presented by MHC-I related protein 1 (MR1), via an αβ T cell receptor (TCR). MAIT TCRs feature an essentially invariant TCR α-chain, which is highly…

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Mapping the interaction sites of human and avian influenza A viruses and complement factor H

The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical, lectin and alternative pathways. Consequently, many pathogens bind to or incorporate in their structures host…

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Re-emergence of foot-and-mouth disease in the Republic of Korea caused by the O/ME-SA/Ind-2001e lineage

The O/ME-SA/Ind-2001e foot-and-mouth disease virus (FMDV) lineage is a pandemic strain that has recently become dominant within East and Southeast Asia. During May 2023, this viral lineage spread to the Republic of Korea, where 11 outbreaks were detected on cattle and goat…

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Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa

Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have sequenced the whole…

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Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa

Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have sequenced the whole…

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Regulation of Wnt/β-catenin signaling by Marek's disease virus in vitro and in vivo

Marek’s disease virus (MDV) infection causes immunosuppression in the host, ultimately inducing tumor formation and causing significant economic losses to the poultry industry. While the abnormal activation of the Wnt/β-catenin signaling pathway is closely associated with…