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Rinderpest virus expressing enhanced green fluorescent protein as a separate transcription unit retains pathogenicity for cattle

A full-length DNA clone of a virulent strain of rinderpest virus was constructed with the gene for the enhanced green fluorescent protein (eGFP) inserted as a separate transcription unit between the P and M genes. Rescue of the virus from the modified clone using reverse…

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The feasibility of developing a risk assessment for the impact of climate change on the emergence of Crimean-Congo haemorrhagic fever in livestock in Europe: a review

Crimean-Congo haemorrhagic fever virus (CCHFV) is one of the most widespread of all medically important arboviruses with ticks of the Hyalomma spp. serving as the main vectors. Infection of livestock by CCHFV serves as a route of exposure to humans, as a reservoir of disease…

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Exploring pig trade patterns to inform the design of risk-based disease surveillance and control strategies

An understanding of the patterns of animal contact networks provides essential information for the design of risk-based animal disease surveillance and control strategies. This study characterises pig movements throughout England and Wales between 2009 and 2013 with a view…

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Host genetics determine susceptibility to avian influenza infection and transmission dynamics

Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to…

Control of African horse sickness improved with rapid, reliable diagnostic test

Researchers at The Pirbright Institute have developed a field test for African horse sickness (AHS) that is reliable, fast and simple to use. African horse sickness (AHS) is a viral disease that infects all equine species and is often fatal in horses and mules. It has become…

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Development of a novel reverse transcription loop-mediated isothermal amplification assay for the rapid detection of African horse sickness virus

African horse sickness (AHS) is a disease of equids caused by African Horse Sickness Virus (AHSV) and is transmitted by Culicoides midges. AHS is endemic in sub-Saharan Africa, but during the past century, outbreaks of significant economic importance and elevated mortality…

Pirbright scientists train Tanzanian centre to gain OIE status

Scientists from The Pirbright Institute are paving the way for a regional OIE (World Organisation for Animal Health) reference laboratory in Tanzania by training local scientists to further advance their diagnostic capability of Peste des petit ruminants virus (PPRV) in the…

Genes may give some birds greater resistance to flu

New research carried out at The Pirbright Institute indicates that the genes of some chickens makes them almost resistant to bird flu. The findings, which are published in the journal Scientific Reports, show that genetics play a key part in whether the birds are susceptible…

World Zoonoses Day: The Pirbright Institute’s research leads the way in improving animal and human health

Understanding, controlling and eradicating diseases that affect animals has never been more important in helping protect human health as well, said The Pirbright Institute on World Zoonoses Day on Wednesday 6 July 2016. Over the last ten years experts estimate that three…

UK better prepared for a potential bluetongue virus outbreak than ever before

The UK has learnt many lessons from the bluetongue virus outbreak of 2006, and supported by The Pirbright Institute, is better prepared than ever to prevent or control a possible new outbreak, Dr Simon Carpenter from the Institute has said. Speaking at the 2016 World…