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Influence of age and dose of African swine fever virus infections on clinical outcome and blood parameters in pigs

African swine fever (ASF) is a fatal disease for domestic pigs, leading to serious economic losses in countries where ASF is endemic. Despite extensive research, efficient vaccines against ASF are lacking. Since peripheral blood cells are important mediators for vaccines, we…

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Severe outbreak of Marek's disease in crested partridges (Rollulus rouloul)

MAREK'S disease (MD) is a well-recognised disease in poultry worldwide caused by gallid herpesvirus 2 (GaHV-2), also known as Marek's disease virus serotype 1 (MDV-1), and can result in significant losses in poultry. Following the introduction of MD virus (MDV) vaccines, the…

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Identification of genes for engineering the male germline of Aedes aegypti and Ceratitis capitata

Synthetic biology approaches are promising new strategies for control of pest insects that transmit disease and cause agricultural damage. These strategies require characterised modular components that can direct appropriate expression of effector sequences, with components…

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Targeted editing of avian herpesvirus vaccine vector using CRISPR/Cas9 nuclease

Herpesvirus of turkey (HVT) is an avian alphaherpesvirus used as live vaccine against Marek's disease for more than 40 years. HVT is also widely used as a vector platform for generation of recombinant vaccines against other avian diseases using conventional recombination…

Pirbright Institute “delighted” to win share of £120m Government vaccine fund

The Pirbright Institute is one of the largest recipients of the Government’s new £120 million fund to fight deadly diseases – winning £1.580 million with its partners, for a joint project to develop a safe and effective livestock vaccine against Rift Valley fever. Rift…

Pirbright study to improve the production and supply of foot-and-mouth disease vaccine

Researchers at The Pirbright Institute have secured almost $1.5 million from the Bill and Melinda Gates Foundation to fund the development of improved foot-and-mouth disease (FMD) vaccines for East Africa. The project, headed by Dr Bryan Charleston, Interim Director and CEO…

Infection route is key to testing effectiveness of swine flu vaccines

Studies assessing the effectiveness of anti-viral treatments for swine flu and those seeking to understand the behaviour of the virus, must factor in the route of infection during experiments, as this has a greater impact on results than previously thought, a new study from…

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Molecular and epidemiological features of peste des petits ruminants outbreak during endemic situation

An outbreak of peste des petits ruminants (PPR), possibly caused by the introduction of new animals in the herd, was investigated in an unvaccinated mixed herd of sheep and goats. Goats in the herd showed characteristic signs of PPR including nasal and ocular discharges…

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Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016)

This article lists the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in April 2016. Changes to virus taxonomy (the Universal Scheme of Virus Classification of the International Committee on Taxonomy of Viruses…

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Progress and knowledge gaps in Culicoides genetics, genomics and population modelling: 2003 to 2014

In the 10 years, since the last international meeting on Bluetongue virus (BTV) and related Orbiviruses in Sicily, there have been huge advances in explorations of the genetics and genomics of Culicoides, culminating in the imminent release of the rst full genome de novo…