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Comparing Phylogeographies to Reveal Incompatible Geographical Histories within Genomes

Modern phylogeography aims at reconstructing the geographic movement of organisms based on their genomic sequences and spatial information. Phylogeographic approaches are often applied to pathogen sequences and therefore tend to neglect the possibility of recombination…

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Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR is counteracted by the upregulation of growth arrest and DNA damage…

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Viral miRNA delivered by exosomes from Marek’s disease virus-transformed lymphoma cell line exerts regulatory function in internalized primary chicken embryo fibroblast cells

In the past decade, research has demonstrated that viral miRNAs encoded by a number of viral genomes, particularly by most of the herpesvirus including Marek’s disease virus (MDV), play important regulatory roles in viral infection, replication, and regulation of…

Pink pigs snuffling on mud at dusk

New insights into immune responses

New insights into our immune responses could pave the way for innovative treatments and vaccines. Research by Pirbright scientists, as part of an international collaboration, has informed a new paper published in the Journal of Biological Chemistry. The study shows an…

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Brain invasion of bovine coronavirus: molecular analysis of bovine coronavirus infection in calves with severe pneumonia and neurological signs

Importance: Although the role of bovine coronavirus (BCoV) in calf diarrhea and respiratory disorders is well documented, its contribution to neurological diseases is unclear. Objective: This study conducted virological investigations of calves showing diarrhea and…

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Pupal Exuviae of Culex Pipiens L. (Diptera: Culicidae) Can be Utilised as a Non-Invasive Method of Biotype Differentiation

Background: Culex pipiens L. is a principal vector of zoonotic arboviruses in Europe, acting in both an amplification role in enzootic transmission between avian hosts and as a bridge vector between avian hosts and mammals. The species consists of two forms which are…

A tribute to former Pirbright director, Professor Brian Mahy

The former Director of the Animal Virus Research Institute at Pirbright, Professor Brian Wilfred John Mahy, BSc, PhD, MA, DSc, has died at the age of 87. After gaining his PhD in 1963 at the University of Southampton, Brian started his career at the University of London as a…

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Immune escape of avian oncogenic Marek's disease herpesvirus and antagonistic host immune responses

Marek's disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek's disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry. The onset of MD lymphomas and other clinical diseases can…

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Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre

Foot-and-mouth disease (FMD) outbreaks affecting Asiatic black bears (Ursus thibetanus) and a Malayan sun bear (Helarctos malayanus) were previously reported in 2011 in two housing facilities at a Vietnamese bear rescue centre. In this study, demographic data of all animals…

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Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre

Foot-and-mouth disease (FMD) outbreaks affecting Asiatic black bears (Ursus thibetanus) and a Malayan sun bear (Helarctos malayanus) were previously reported in 2011 in two housing facilities at a Vietnamese bear rescue centre. In this study, demographic data of all animals…