Search | The Pirbright Institute

Filters

default publication image

Bluetongue: Aetiology, Epidemiology, Pathogenesis, Diagnosis and Control (chapter 1)

Bluetongue (BT) is an emerging and re-emerging vector-borne viral disease of domestic and wild ruminants, caused by viruses classified within the species bluetongue virus (BTV), genus Orbivirus, family Reoviridae. There are 27 recognized serotypes of BTV (with two more…

default publication image

Genetic diversity and comparison of diagnostic tests for characterization of foot-and-mouth disease virus strains from Pakistan 2008 - 2012

We report the laboratory analysis of 125 clinical samples from suspected cases of foot-and-mouth disease (FMD) in cattle and Asian buffalo collected in Pakistan between 2008 and 2012. Of these samples, 89 were found to contain viral RNA by rRT-PCR, of which 88 were also…

default publication image

Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Chlamydiales and Leishmania

Medical countermeasures to treat biothreat agent infections require broad-spectrum therapeutics that do not induce agent resistance. A cell-based high-throughput screen (HTS) against ricin toxin combined with hit optimization allowed selection of a family of compounds that…

Foot-and-mouth disease virus capsid structure

Protein shown vital for foot-and-mouth disease virus replication

Researchers at The Pirbright Institute have shown that when drugs are used to inhibit the cellular protein, hsp90, foot-and-mouth disease virus (FMDV) production is reduced. Hsp90 is a protein used by cells to fold other proteins correctly and it was shown to be required by…

Pirbright team with UAR public engagement award

Pirbright wins award for openness on animal research project

On Monday 4 December, The Pirbright Institute jointly won the Public Engagement category at the fourth annual Understanding Animal Research (UAR) Openness Awards for its contribution to the 360° Laboratory Animal Tours project. The Openness Awards mark the efforts of UK…

BRSV infected calf lung

Pirbright collaboration shows immune system can worsen respiratory disease

Scientists from The Pirbright Institute, in collaboration with others, have found immune cells designed to help clear infections could actually be aggravating respiratory disease caused by bovine respiratory syncytial virus (BRSV). The virus infects the lungs of cattle and…

default publication image

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

Infectious bursal disease virus (IBDV) belongs to the family Birnaviridae and is economically important to the poultry industry worldwide. IBDV infects B cells in the bursa of Fabricius (BF), causing immunosuppression and morbidity in young chickens. In addition to strains…

default publication image

Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007-2012) circulating in Southeast Asia, East Asia and Far East

Foot-and-mouth disease (FMD) is endemic in Southeast Asia (SEA) and East Asia with circulation of multiple serotypes and multiple genotypes within each serotype of the virus. Although countries like Japan and South Korea in the Far East were free of FMD, in 2010 FMD serotype…

default publication image

Genetic characterization of canine parvovirus from dogs in Pakistan

Canine parvoviruses (CPV) exist as antigenic variants with varying frequencies and genetic variabilities across the globe. Given the endemicity and high prevalence in Pakistan, we characterized the CPVs originating from dogs-population to elucidate viral diversity and…

default publication image

Avian leukosis virus subgroup J-associated myelocytoma in a hobby chicken

The avian leukosis viruses (ALVs) are a major group of retroviruses associated with neoplastic diseases in poultry. The ALV-J strain was identified as a cause of myelocytomas in broiler breeder and broiler chickens in the UK in the 1980s; however, following eradication of…