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Interaction of porcine monocyte-derived dendritic cells with African swine fever viruses of diverse virulence

African swine fever (ASF) is a devastating disease for which there is no vaccine. The ASF virus (ASFV) can infect dendritic cell (DC), but despite the critical role these cells play in induction of adaptive immunity, few studies investigated their response to ASFV infection…

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Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

In response to viral infection, cells mount a potent inflammatory response that relies on ISG15 and ubiquitin posttranslational modifications. Many viruses use deubiquitinases and deISGylases that reverse these modifications and antagonize host signaling processes. We here…

foot-and-mouth disease infected cell

Foot-and-mouth disease protein could be used for disease detection

Dr Stephen Berryman and Dr Toby Tuthill from The Pirbright Institute have collaborated with the MRC Laboratory of Molecular Biology and other research institutes* to uncover a new system used by the foot-and-mouth disease virus (FMDV) to prevent antiviral signalling of…

Cells infected with African swine fever

Advance in the hunt for African swine fever vaccine

Researchers from The Pirbright Institute have made a promising step forward by identifying key African swine fever virus (ASFV) proteins that induce immune responses in pigs. ASFV is an extremely severe and economically important disease of domestic pigs, which is usually…

Foot-and-mouth disease

Diagnosis of foot-and-mouth disease (FMD): Instructor-led

Learn FMDV isolation, detection, genome analysis, and vaccine matching.

Scientist at bench

Transboundary diseases: Instructor-led

Learn quality management, virus isolation, ELISA, and PCR techniques.

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The application of NHEJ-CRISPR/Cas9 and Cre-Lox system in the generation of bivalent duck enteritis virus vaccine against avian influenza virus

Duck-targeted vaccines to protect against avian influenza are critically needed to aid in influenza disease control efforts in regions where ducks are endemic for highly pathogenic avian influenza (HPAI). Duck enteritis virus (DEV) is a promising candidate viral vector for…

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Immunisation of pigs by DNA prime and recombinant vaccinia virus boost to identify and rank African swine fever virus immunogenic and protective proteins

African swine fever virus (ASFV) causes an acute haemorrhagic fever in domestic pigs with high socio-economic impact. No vaccine is available limiting options for control. Although live attenuated ASFV can induce up to one hundred percent protection against lethal challenge…

White chicken

Poultry keepers need to be vigilant to combat the spread of bird flu in the UK

The recent H5N6 bird flu outbreak is confined to the south of England, partly due to the introduction of an Avian Influenza Protection Zone in England and Wales including strict biosecurity measures for affected bird keepers. But what is bird flu? Why is it such a threat…

Cows in a field at Pirbright Compton site

Pirbright helps demonstrate the UK remains free from bluetongue virus

Scientists at The Pirbright Institute have played a key role in providing assurance that the UK remains free from bluetongue following the positive test results of four cattle which had moved from France into the north of England and Scotland in October 2017 without…