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Pig immunology comes of age: killer T cell responses to influenza

Researchers from The Pirbright Institute, University of Bristol, Cardiff University and University of Oxford have generated tools that allow scientists to understand a vital area of the pig immune system which was previously inaccessible. The breakthrough research, described…

babraham pigs flu

Pig immunology comes of age: killer T cell responses to influenza

Researchers from The Pirbright Institute, University of Bristol, Cardiff University and University of Oxford have generated tools that allow scientists to understand a vital area of the pig immune system which was previously inaccessible. The breakthrough research, described…

babraham pigs flu

Pig immunology comes of age: killer T cell responses to influenza

Researchers from The Pirbright Institute, University of Bristol, Cardiff University and University of Oxford have generated tools that allow scientists to understand a vital area of the pig immune system which was previously inaccessible. The breakthrough research, described…

Pipetting at bench

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A naturally occurring deletion in the effector domain of H5N1 swine influenza virus nonstructural protein 1 regulates viral fitness and host innate immunity

Nonstructural protein 1 (NS1) of influenza A virus regulates innate immune responses via various mechanisms. We previously showed that a naturally occurring deletion (the EALQR motif) in the NS1 effector domain of an H5N1 swine-origin avian influenza virus impairs the…

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Functional alleles of chicken BG genes, members of the butyrophilin gene family, in peripheral T cells

γδ T cells recognize a wide variety of ligands in mammals, among them members of the butyrophilin (BTN) family. Nothing is known about γδ T cell ligands in chickens, despite there being many such cells in blood and lymphoid tissues, as well as in mucosal surfaces. The major…

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Comparison of heterosubtypic protection in ferrets and pigs induced by a single cycle influenza vaccine

Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive…

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Chicken interferon-induced protein with tetratricopeptide repeats 5 antagonizes replication of RNA viruses

The intracellular actions of interferon (IFN)-regulated proteins, including IFN-induced proteins with tetratricopeptide repeats (IFITs), attribute a major component of the protective antiviral host defense. Here we applied genomics approaches to annotate the chicken IFIT…

Dr Erica Bickerton egg candling

New method for infectious bronchitis vaccine production funded

Scientists at The Pirbright Institute have been awarded over £300,000 to develop a faster and more efficient method for infectious bronchitis virus (IBV) vaccine production. The virus causes a poultry respiratory disease which is the most economically important infectious…

African domestic cows in Tanzania

Pirbright identifies two new genetic groups of foot-and-mouth disease virus

Researchers from The Pirbright Institute have examined the genetic material of foot-and-mouth disease virus (FMDV) samples collected from eastern and southern Africa, and discovered two novel virus groups. These new groups, termed genotypes, will help scientists to…