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Globe and vaccine vials

Pandemics

Fighting killer diseases A pandemic is a worldwide spread of a new disease. Flu is the most well known - the 2009 swine flu pandemic killed over 200,000 people worldwide. Pandemics can have a devastating effect on the lives of people and animals around the world. Pandemics…

pig looking close up

Pigs as universal flu vaccine models

Researchers from The Pirbright Institute collaborated with the University of Oxford and the National Institutes of Health, USA, to show that S-FLU, a universal flu vaccine candidate, induces different immune responses in pigs compared to ferrets, raising the possibility that…

pig looking close up

Pigs as universal flu vaccine models

Researchers from The Pirbright Institute collaborated with the University of Oxford and the National Institutes of Health, USA, to show that S-FLU, a universal flu vaccine candidate, induces different immune responses in pigs compared to ferrets, raising the possibility that…

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Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018)

This article lists the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses in February 2018. A total of 451 species, 69 genera, 11 subfamilies, 9 families and one new order were added to the taxonomy. The current totals at…

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Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Rhinoviruses (RVs) are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report the discovery of IMP-1088, a picomolar dual inhibitor of the human…

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AMP-activated protein kinase mediates the effect of leptin on avian autophagy in a tissue-specific manner

Autophagy, a highly conserved intracellular self-digestion process, plays an integral role in maintaining cellular homeostasis. Although emerging evidence indicate that the endocrine system regulates autophagy in mammals, there is still a scarcity of information on autophagy…

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Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current…

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Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current…

default publication image

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current…

default publication image

Inhibition of v-rel-Induced oncogenesis through microRNA targeting

Several studies have shown that microRNA-targeting is an effective strategy for the selective control of tissue-tropism and pathogenesis of both DNA and RNA viruses. However, the exploitation of microRNA-targeting for the inhibition of transformation by oncogenic viruses has…