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Recombinant infectious bronchitis viruses expressing chimaeric spike glycoproteins induce partial protective immunity against homologous challenge despite limited replication in vivo

Vaccination regimes against infectious bronchitis virus, which are based on a single virus serotype, often induce insufficient levels of cross-protection against serotypes and two or more antigenically diverse vaccines are used in attempt to provide broader protection. Amino…

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Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate

Foot-and-mouth disease virus (FMDV) is highly contagious and infects cloven-hoofed domestic livestock leading to foot-and-mouth disease (FMD). FMD outbreaks have severe economic impact due to production losses and associated control measures. FMDV is found as seven distinct…

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Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate

Foot-and-mouth disease virus (FMDV) is highly contagious and infects cloven-hoofed domestic livestock leading to foot-and-mouth disease (FMD). FMD outbreaks have severe economic impact due to production losses and associated control measures. FMDV is found as seven distinct…

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Foot-and-mouth disease outbreaks due to an exotic virus serotype A lineage (A/AFRICA/G-IV) in Algeria in 2017

This study describes the genetic characterization of serotype A viruses collected during outbreaks of foot-and-mouth disease (FMD) that occurred in Algeria in 2017. These are the first reports of clinical cases due to this serotype in the country since 1977. One complete…

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Direct growth inhibitory effect of platelet activating factor C-16 and its structural analogues on Mycobacteria

Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the leading causes of human deaths due to a single infectious agent. M. tuberculosis infection of the host initiates a local inflammatory response, resulting in the production of a range of…

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First molecular characterisation of avian metapneumovirus (aMPV) in Turkish broiler flocks

Viral respiratory diseases including avian metapneumovirus (aMPV) have a significant economic impact on poultry industries. The frequency and genotype diversity of aMPV in Turkish broiler flocks is not known at present. The aim of this study was to report the first molecular…

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Pirbright switches it up: creating foot-and-mouth disease hybrids for better vaccines

In collaborative research led by The Pirbright Institute, scientists have generated a ‘hybrid’ foot-and-mouth disease virus (FMDV) with improved stability, which will increase its effectiveness when administered as a vaccine. They targeted the Southern African Territories…

foot-and-mouth disease virus pink blue grey

Pirbright switches it up: creating foot-and-mouth disease hybrids for better vaccines

In collaborative research led by The Pirbright Institute, scientists have generated a ‘hybrid’ foot-and-mouth disease virus (FMDV) with improved stability, which will increase its effectiveness when administered as a vaccine. They targeted the Southern African Territories…

A revival for comparative and veterinary immunology

Under the leadership of Pirbright’s Dr Elma Tchilian the Comparative and Veterinary Immunology Group (CVIG) has been revived and is actively engaging in opportunities to showcase the research of its members and bring knowledge of comparative and veterinary immunology to a…

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Impact of foot-and-mouth disease on fertility performance in a large dairy herd in Kenya

This was a retrospective cohort study using data collected from a large-scale dairy herd in Kenya (n = 328 female animals), to investigate the effects of foot-and-mouth disease (FMD) on herd fertility performance following a confirmed outbreak in a regularly vaccinated herd…