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Pirbright hosts inaugural immunology meeting

The Pirbright Institute hosted the inaugural Comparative Veterinary Immunology Group (CVIG) meeting ‘ Frontiers in Human and Veterinary Antibody discovery’ on 26 and 27 November, 2018 where 120 renowned immunologists from around the world congregated to share knowledge and…

Pirbright student wins award to study the role of insects in lumpy skin disease infection

First year PhD student Charlotte Cook was recently thrilled to learn that she is being given an In Vivo Skills Award from the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI). Only three such awards are offered by the…

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The development of two field-ready reverse transcription loop-mediated isothermal amplification assays for the rapid detection of Seneca Valley virus 1

Seneca Valley virus 1 (SVV-1) has been associated with vesicular disease in swine, with clinical signs indistinguishable from those of other notifiable vesicular diseases such as foot-and-mouth disease. Rapid and accurate detection of SVV-1 is central to confirm the disease…

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Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis

IFNγ is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFNγ receptor (IFNγR -/-) at a dose which caused severe disease in wild type 129Sv/Ev (WT) mice resulted in…

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Evolution of codon usage bias in henipaviruses is governed by natural selection and is host-specific

Hendra virus (HeV) and Nipah virus (NiV) are among a group of emerging bat-borne paramyxoviruses that have crossed their species-barrier several times by infecting several hosts with a high fatality rate in human beings. Despite the fatal nature of their infection, a…

inter institute imaging group

Pirbright hosts first Inter-Institute Imaging Network

The first meeting of the Inter-Institute Imaging Network (IIIN) was recently held at The Pirbright Institute to promote collaboration between its partners in the field of bioimaging. Delegates from the Biotechnology and Biological Sciences Research Council institutes and…

yellow chick at pirbright in housing

Bird flu viruses could escape vaccine immunity while increasing potential to infect humans

Research led by The Pirbright Institute has shown mutant H9N2 bird flu viruses isolated from Pakistan are able to escape immune responses and adapt to infect humans. This could result in reduced vaccine efficiency and the possibility of human outbreaks. Published in the…

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Recombinant infectious bronchitis viruses expressing heterologous S1 subunits: potential for a new generation of vaccines that replicate in Vero cells

The spike glycoprotein (S) of infectious bronchitis virus (IBV) comprises two subunits, S1 and S2. We have previously demonstrated that the S2 subunit of the avirulent Beau-R strain is responsible for its extended cellular tropism for Vero cells. Two recombinant infectious…

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Chicken anaemia virus evades host immune responses in transformed lymphocytes

Chicken anaemia virus (CAV) is a lymphotropic virus that causes anaemia and immunosuppression in chickens. Previously, we proposed that CAV evades host antiviral responses in vivo by disrupting T-cell signalling, but the precise cellular targets and modes of action remain…

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Development of cross-protective Eimeria-vectored vaccines based on apical membrane antigens

Recently, the availability of protocols supporting genetic complementation of Eimeria has raised the prospect of generating transgenic parasite lines which can function as vaccine vectors, expressing and delivering heterologous proteins. Complementation with sequences…