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Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus

Equine encephalosis (EE) is an acute, arthropod-borne, noncontagious, febrile disease of equids. The clinical signs of EE are similar to milder forms of African horse sickness (AHS) and the two diseases can be easily confused. The Equine encephalosis virus (EEV) is a…

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Additional changes to taxonomy ratified in a special vote by the International Committee on Taxonomy of Viruses (October 2018)

This article reports the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in October 2018. Of note, the ICTV has approved, by an absolute majority, the creation of additional taxonomical ranks above those recognized…

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Considerations for design and implementation of vaccine field trials for novel foot-and-mouth disease vaccines

Vaccines are commonly used to control Foot-and-Mouth Disease (FMD) in endemic regions and form an important part of contingency plans for FMD-free countries. Conventional FMD vaccines have numerous limitations, and the U.S. government supports the development of next…

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The cellular localisation of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells

The accessory protein, PB1-F2, of influenza A virus (IAV) functions in a chicken host to prolong infectious virus shedding and thus the transmission window. Here we show that this delay in virus clearance by PB1-F2 in chickens is accompanied by reduced transcript levels of…

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Genome sequences of antigenically distinct serotype O foot-and-mouth disease viruses from Pakistan

The genome sequences of three serotype O foot-and-mouth disease viruses (FMDVs) isolated from outbreaks in Pakistan in 2016 and 2017 are described. Despite all three isolates being classified in the same FMDV genetic sublineage, two of them displayed a distinct antigenic…

DARPA awards Pirbright $2.6 million to prevent mosquito-borne diseases

The Pirbright Institute has received an award worth up to $2.6 million to develop proof-of-concept tools that could prevent mosquitoes from transmitting a broad range of viruses. The project forms part of DARPA’s Preventing Emerging Pathogenic Threats (PREEMPT) programme…

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Clade 2.3.2.1 H5N1 avian influenza viruses circulate at the interface of migratory and domestic birds around Qinghai Lake in China

During 2012-2015, six H5N1 avian influenza viruses were isolated from domestic birds and the environment around Qinghai Lake. Phylogenetic analysis of HA genes revealed that A/chicken/Gansu/XG2/2012 (CK/GS/XG2/12) belonged to clade 2.3.2.1a, while A/environment/Qinghai/1…

Dr Pip Beard researcher and scientist at pirbirght feature

Science Spotlight: Dr Pip Beard

Dr Pip Beard’s research is focused on the control and prevention of animal diseases caused by large DNA viruses. Her group concentrates on African swine fever and lumpy skin disease, two viral diseases which have severe impacts across the globe on the welfare of livestock…

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Evidence of reduced viremia, pathogenicity and vector competence in a re-emerging European strain of bluetongue virus serotype 8 in sheep

The outbreak of bluetongue virus (BTV) serotype 8 (BTV-8) during 2006-2009 in Europe was the most costly epidemic of the virus in recorded history. In 2015, a BTV-8 strain re-emerged in France which has continued to circulate since then. To examine anecdotal reports of…

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Evidence of reduced viremia, pathogenicity and vector competence in a re-emerging European strain of bluetongue virus serotype 8 in sheep

The outbreak of bluetongue virus (BTV) serotype 8 (BTV-8) during 2006-2009 in Europe was the most costly epidemic of the virus in recorded history. In 2015, a BTV-8 strain re-emerged in France which has continued to circulate since then. To examine anecdotal reports of…