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BST2/Tetherin overexpression modulates Morbillivirus glycoprotein production to inhibit cell–cell fusion

The measles virus (MeV), a member of the genus Morbillivirus, is an established pathogen of humans. A key feature of morbilliviruses is their ability to spread by virus–cell and cell–cell fusion. The latter process, which leads to syncytia formation in vitro and in vivo, is…

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Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot

For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes, this process and its…

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SiNPle: fast and sensitive variant calling for deep sequencing data

Current high-throughput sequencing technologies can generate sequence data and provide information on the genetic composition of samples at very high coverage. Deep sequencing approaches enable the detection of rare variants in heterogeneous samples, such as viral quasi…

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Persistent infection of African buffalo (Syncerus caffer) with foot-and-mouth disease virus: limited viral evolution and no evidence of antibody neutralization escape

African buffaloes ( Syncerus caffer) are the principal "carrier" hosts of foot-and-mouth disease virus (FMDV). Currently, the epithelia and lymphoid germinal centres of the oropharynx have been identified as sites for FMDV persistence. We carried out studies in FMDV SAT-1…

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Persistent infection of African buffalo (Syncerus caffer) with foot-and-mouth disease virus: limited viral evolution and no evidence of antibody neutralization escape

African buffaloes ( Syncerus caffer) are the principal "carrier" hosts of foot-and-mouth disease virus (FMDV). Currently, the epithelia and lymphoid germinal centres of the oropharynx have been identified as sites for FMDV persistence. We carried out studies in FMDV SAT-1…

Goats being herded by Maasai

New peste des petits ruminants field test developed by Pirbright scientists

A new method for detecting peste des petits ruminants virus (PPRV) in the field has been developed by scientists at The Pirbright Institute. The novel diagnostic test is as reliable as laboratory tests, provides rapid results and is easy to use in the field. These features…

A man herds cows across land in Tanzania

Pirbright grants licence for new foot-and-mouth disease vaccine

The Pirbright Institute and its research partners have granted MSD Animal Health a commercial licence for a new, effective and affordable vaccine to protect livestock against several serotypes of foot-and-mouth disease virus (FMDV). The new vaccine is more stable than…

ducks and chickens at market

Pirbright scientists identify high risk poultry trading practices for flu in Vietnam

Scientists at The Pirbright Institute have found that the transmission of avian influenza viruses in Vietnam is influenced by the structure of live poultry trading networks. Their work has identified the groups that are most likely to employ trade practices that impact the…

Scientist in full ppe including yellow overalls. They have gloved hands in a secure cabinet and are pipetting

Specialist science facilities

The cutting edge research undertaken at The Pirbright Institute is enabled by a range of highly specialised scientific and animal facilities in both high and low containment environments.

Prof Venu Nair and Dr Zhiqiang Shen CERAD Newton fundUK-China Centre of Excellence for Research of Avian Diseases (CERAD)

Pirbright poultry disease scientist nominated for Newton Prize

Professor Venugopal Nair OBE, Head of the Viral Oncogenesis group at Pirbright is among the shortlisted nominees for the Newton Prize. The award celebrates outstanding international research partnerships and the £1 million prize will be divided between four winning research…