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Pirbight's Plowright building from afar with wild plants in front

Pirbright welcomes two successful Doctoral Landscape Awards in life and environmental sciences

The Pirbright Institute is celebrating two major doctoral training initiatives funded by the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) and Natural Environment Research Council (NERC), each offering unique opportunities for the next generation of…

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Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants

The evolution of SARS-CoV-2 variants with increased fitness has been accompanied by structural changes in the spike (S) proteins, which are the major target for the adaptive immune response. Single-particle cryo-EM analysis of soluble S protein from SARS-CoV-2 variants has…

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Comparative pharmacokinetics of porcine and human anti-influenza hemagglutinin monoclonal antibodies in outbred pigs and minipigs

Assessing the pharmacokinetics of monoclonal antibodies (mAbs) in relevant animal models is essential for designing improved formulations and developing mAb delivery platforms. We have established the pig, a large natural host animal for influenza with many similarities to…

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Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance

H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to clade 2.3.4.4b have caused large outbreaks in avian and multiple nonhuman mammalian species. Previous studies have identified molecular phenotypes of the viral hemagglutinin (HA)…

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Immunisation of chickens with inactivated and/or infectious H9N2 avian influenza virus leads to differential immune B-cell repertoire development

Avian influenza viruses (AIVs) are a major economic burden to the poultry industry and pose serious zoonotic risks, with human infections being reported every year. To date, the vaccination of birds remains the most important method for the prevention and control of AIV…

Close up of a pipette tip in a well of gel electrophoresis. Blue liquid is visible in the wells.

Nurturing emerging leaders in science

Two talented Pirbright researchers have been awarded with Strategic Career Development Awards (SCDAs) to advance their research and career trajectories. Dr Rory Fortes de Brito, a Senior Postdoctoral researcher in the Porcine Reproductive and Respiratory Syndrome (PRRS)…

Cattle and goats in Tanzania

Pirbright joins UKRI-backed network to tackle livestock diseases

The Pirbright Institute is joining a new network which aims to help detect, predict and prevent viral diseases that threaten animals. Funded by UK Research and Innovation (UKRI) the One Health Computational Network (OHCN) is an interdisciplinary project strengthening UKRI’s…

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Corrigendum to “Evaluation of commercial quadrivalent foot-and-mouth disease vaccines against east African virus strains reveals limited immunogenicity and duration of protection” [Vaccine 42 (1–12) (2024) 126325]

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No evidence that mutations in SARS-CoV-2 variants of concern derive from homologous fragments in gut microbiota

Understanding the origin and evolution of mutations in SARS-CoV-2 variants of concern (VOCs) is a critical area of research. B. Cao, X. Wang, W. Yin, Z. Gao, and B. Xia (mBio 15:e03187-23, 2024, https://doi.org/10.1128/mbio.03187-23) proposed that these mutations originated…

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Development of bovine IgG3-specific assays using a novel recombinant single-domain binding reagent

Cattle express three subclasses of IgG antibody - IgG1, IgG2 and IgG3. Unlike IgG1 and IgG2, IgG3 was described relatively recently and the role of this subclass in immunity is unknown. Using recombinant bovine IgG1, IgG2 and IgG3 monoclonal antibodies (mAbs), we…