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Viral miRNA delivered by exosomes from Marek's disease virus-transformed lymphoma cell line exerts regulatory function in internalized primary chicken embryo fibroblast cells

In the past decade, research has demonstrated that viral miRNAs encoded by a number of viral genomes, particularly by most of the herpesvirus including Marek's disease virus (MDV), play important regulatory roles in viral infection, replication, and regulation of…

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Clinical disease in British sheep infected with an emerging strain of bluetongue virus serotype 3

Background Bluetongue virus serotype 3 (BTV-3) was detected for the first time in cattle and sheep in southern England in 2023, the first UK BTV incursion for more than 15 years. Clinical signs were not observed, yet severe clinical disease and mortality were reported during…

Research offers hope for future African swine fever vaccine

Scientists have gained new insights into African swine fever virus (ASFV), a deadly pathogen that causes major losses in global pig farming and threatens global food security. A study, led by The Pirbright Institute and published today in mBio, uses a novel strategy to make…

Research offers hope for future African swine fever vaccine

Scientists have gained new insights into African swine fever virus (ASFV), a deadly pathogen that causes major losses in global pig farming and threatens global food security. A study, led by The Pirbright Institute and published today in mBio, uses a novel strategy to make…

Research offers hope for future African swine fever vaccine

Scientists have gained new insights into African swine fever virus (ASFV), a deadly pathogen that causes major losses in global pig farming and threatens global food security. A study, led by The Pirbright Institute and published today in mBio, uses a novel strategy to make…

flock of chickens on grass

Pirbright workshop explores avian flu control

A workshop hosted by The Pirbright Institute convened world-leading experts to explore ways of reducing the impact of bird flu on livestock, poultry production and human health. Hosted at the Institute’s site in Surrey, the two-day event brought together international…

Three sheep in a field

Study confirms the clinical impact of a BTV-3 outbreak on the UK sheep population

A new study highlights the potentially serious consequences of bluetongue virus serotype 3 (BTV-3) on the UK sheep population. This BTV-3 strain emerged in Northern Europe in September 2023 and has since been reported in 16 countries across the continent, causing outbreaks…

Three sheep in a field

Study confirms the clinical impact of a BTV-3 outbreak on the UK sheep population

A new study highlights the potentially serious consequences of bluetongue virus serotype 3 (BTV-3) on the UK sheep population. This BTV-3 strain emerged in Northern Europe in September 2023 and has since been reported in 16 countries across the continent, causing outbreaks…

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Evaluation of commercial quadrivalent foot-and-mouth disease vaccines against east African virus strains reveals limited immunogenicity and duration of protection

Foot-and-mouth disease virus (FMDV) causes a contagious disease (FMD) in cloven-hoofed animals. For FMD-endemic countries, vaccination is critical for controlling disease but is rarely monitored, despite substantial funds spent on vaccine purchases. We evaluated antibody…

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High pathogenicity avian influenza H5N5: the next threat?