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Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection

Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosome profiling to…

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Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection

Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosome profiling to…

a vaccine vial on blue background with overlayed text saying 'One health vaccinology, the key to preventing future pandemics?

Pirbright collaboration illuminates path to preventing future pandemics through ‘One Health vaccinology’

The COVID-19 pandemic has provided yet another stark reminder that more than 70 percent of human infectious diseases emerge from animal populations. It has further emphasised the need for a more holistic approach to developing vaccines and treatments that could improve the…

A diagram showing how a yellow tetramer with a green virus segment attached to each of its four arms is able to be recognised by a blue T cell.

Pirbright scientists use ‘molecular magnets’ to discover FMD virus segments that could improve vaccine effectiveness

Recent research from The Pirbright Institute has revealed new parts of the foot-and-mouth disease virus (FMDV) that stimulate an immune response, which could be used to inform the design of improved vaccines. They also discovered that specific immune cells were present in…

Plowright building

New Animal Vaccine Manufacturing and Innovation Centre to be established at Pirbright

A landmark global health declaration by G7 leaders, which was agreed at the G7 meeting in Carbis Bay, includes a commitment to ensure that the global devastation caused by COVID-19 is never repeated and the creation of a new centre to develop vaccines to prevent zoonotic…

A black outline of a pig on a background that shows red ASF virus particles

Pirbright twins with Philippines to improve African swine fever control

On 10 June 2021, experts at The Pirbright Institute kicked off a new World Organisation for Animal Health (OIE) twinning project with the Animal Disease Diagnosis and Reference Laboratory, part of the Bureau of Animal Industry’s Veterinary Laboratory Division (BAI- VLD-…

A black outline of a pig on a background that shows red ASF virus particles

Pirbright twins with Philippines to improve African swine fever control

On 10 June 2021, experts at The Pirbright Institute kicked off a new World Organisation for Animal Health (OIE) twinning project with the Animal Disease Diagnosis and Reference Laboratory, part of the Bureau of Animal Industry’s Veterinary Laboratory Division (BAI- VLD-…

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Culex quinquefasciatus: status as a threat to island avifauna and options for genetic control

The avifauna endemic to islands is particularly susceptible to population declines and extinctions resulting from the introduction of non-native pathogens. Three pathogens of concern are the avian malaria parasites, the avian poxviruses, and West Nile virus— each of which…

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An early block in the replication of the atypical bluetongue virus serotype 26 in Culicoides cells is determined by its capsid proteins

Arboviruses such as bluetongue virus (BTV) replicate in arthropod vectors involved in their transmission between susceptible vertebrate-hosts. The “classical” BTV strains infect and replicate effectively in cells of their insect-vectors (Culicoides biting-midges), as well as…

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African swine fever virus genotype II in Mongolia, 2019

African swine fever (ASF) is a severe haemorrhagic disease of domestic and wild pigs caused by the African swine fever virus (ASFV). In recent years, ASF has steadily spread towards new geographical areas, reaching Europe and Asia. On January 15th, 2019, Mongolia reported…