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Innate immune antagonism of mosquito-borne flaviviruses in humans and mosquitoes

Mosquito-borne viruses of the Flavivirus genus ( Flaviviridae family) pose an ongoing threat to global public health. For example, dengue, Japanese encephalitis, West Nile, yellow fever, and Zika viruses are transmitted by infected mosquitoes and cause severe and fatal…

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First genomic evidence of dual African swine fever virus infection: case report from recent and historical outbreaks in Sardinia

African swine fever virus (ASFV) is one of the pathogens of highest concern worldwide. Despite different virus lineages co-circulating in several areas, dual infections in the same animal have been rarely observed, suggesting that ASF superinfections are infrequent events…

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Ongoing assessment of the molecular evolution of peste des petits ruminants virus continues to question viral origins

Understanding the evolution of viral pathogens is critical to being able to define how viruses emerge within different landscapes. Host susceptibility, which is spread between different species and is a contributing factor to the subsequent epidemiology of a disease, is…

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Identification and characterization of a novel epitope of ASFV-encoded dUTPase by monoclonal antibodies

Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) of African swine fever virus (ASFV) is an essential enzyme required for efficient virus replication. Previous crystallography data have indicated that dUTPase (E165R) may serve as a therapeutic target for inhibiting…

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A deeper insight on evolutionary patterns and phylogenetic history of ASFV epidemics in Sardinia (Italy) through extensive genomic sequencing.

African swine fever virus (ASFV) is the etiological agent of the devastating disease African swine fever (ASF), for which there is currently no licensed vaccine or treatment available. ASF is defined as one of the most serious animal diseases identified to date, due to its…

A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles are coloured red, the rest of the cell image is purple.

Zika virus

Zika virus (ZIKV) is primarily transmitted by mosquitoes in tropical and subtropical regions.

A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles are coloured red, the rest of the cell image is purple.

Zika virus

Zika virus (ZIKV) is primarily transmitted by mosquitoes in tropical and subtropical regions.

Dengue virus electron microscopy image

Dengue virus

Dengue virus (DENV), present predominantly in tropical regions, is primarily transmitted to humans by infected mosquitoes.

Dengue virus electron microscopy image

Dengue virus

Dengue virus (DENV), present predominantly in tropical regions, is primarily transmitted to humans by infected mosquitoes.

Glass model of foot-and-mouth-disease virus (FMDV), lit in purple

Pirbright welcomes three scientific experts to head up new areas of research

Three new research groups have been established at The Pirbright Institute recently, each of which will contribute to the Institute’s mission to prevent and control viral diseases of livestock and viruses that spread from animals to people, known as zoonoses. Discover more…