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Evaluation of the cross-protective efficacy of a chimeric PRRSV vaccine against two genetically diverse PRRSV2 field strains in a reproductive model

Despite the routine use of porcine reproductive and respiratory syndrome (PRRS)-modified live vaccines, serious concerns are currently being raised due to their quick reversion to virulence and limited cross-protection against divergent PRRS virus (PRRSV) strains circulating…

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Protective immunity induced by concurrent intradermal injection of porcine circovirus type 2 and Mycoplasma hyopneumoniae inactivated vaccines in pigs

Vaccines against porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae ( Mhp) are routinely used by intramuscular injection. However, since intramuscular vaccination causes stress and increases the risk of cross-contamination among pigs, research on intradermal…

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Evaluation of a multiplex PCR method for the detection of porcine parvovirus types 1 through 7 using various field samples

Porcine parvoviruses (PPVs) are small, nonenveloped DNA viruses that are widespread in the global pig population. PPV type 1 (PPV1) is a major causative agent of reproductive failure and has been recognized since the 1960s. In recent decades, novel PPVs have been identified…

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Demonstration of co-infection and trans-encapsidation of viral RNA in vitro using epitope-tagged foot-and-mouth disease viruses.

Foot-and-mouth disease, caused by foot-and-mouth disease virus (FMDV), is an economically devastating disease affecting several important livestock species. FMDV is antigenically diverse and exists as seven serotypes comprised of many strains which are poorly cross…

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Coronavirus RNA synthesis takes place within membrane-bound sites

Infectious bronchitis virus (IBV), a gammacoronavirus, is an economically important virus to the poultry industry, as well as a significant welfare issue for chickens. As for all positive strand RNA viruses, IBV infection causes rearrangements of the host cell intracellular…

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Coronavirus RNA synthesis takes place within membrane-bound sites

Infectious bronchitis virus (IBV), a gammacoronavirus, is an economically important virus to the poultry industry, as well as a significant welfare issue for chickens. As for all positive strand RNA viruses, IBV infection causes rearrangements of the host cell intracellular…

default publication image

Marek's disease virus modulates T cell proliferation via activation of cyclooxygenase 2-dependent prostaglandin E2

Marek's disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identified. Here, our results…

Coronavirus particle illustrated in red

Clues about coronavirus replication in host cells uncovered by Pirbright scientists

More clues about coronavirus replication in humans and animals have been uncovered by researchers at Pirbright. This research fills in important knowledge gaps that could help to control disease caused by a range of coronaviruses in the future. When we think of coronaviruses…

Coronavirus particle illustrated in red

Clues about coronavirus replication in host cells uncovered by Pirbright scientists

More clues about coronavirus replication in humans and animals have been uncovered by researchers at Pirbright. This research fills in important knowledge gaps that could help to control disease caused by a range of coronaviruses in the future. When we think of coronaviruses…

Chickens scratching in grass

Avian influenza: tackling large numbers of outbreaks this winter in the UK

Nearly two years on, the COVID-19 pandemic is still dominating the news and continues to cause concern for populations across the globe. However, UK poultry and wild bird populations are currently facing their own health threat. We are not the only ones that have faced…