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Targeted deletion of glycoprotein B gene by CRISPR/Cas9 nuclease inhibits Gallid herpesvirus type 3 in dually-infected Marek's disease virus-transformed lymphoblastoid cell line MSB-1

Marek's disease virus (MDV) is a member of the genus Mardivirus in the subfamily Alphaherpesvirinae. There are 3 different serotypes of MDV designated as MDV-1 ( Gallid herpesvirus type 2), MDV-2 ( Gallid herpesvirus type 3), and MDV-3 ( Meleagrid herpesvirus 1, herpesvirus…

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The Aedes aegypti Domino ortholog p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression

Arboviruses are pathogens of humans and animals. A better understanding of the interactions between these pathogens and the arthropod vectors, such as mosquitoes, that transmit them is necessary to develop novel control measures. A major antiviral pathway in the mosquito…

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The natural cytotoxicity receptor NKp44 (NCR2, CD336) is expressed on the majority of porcine NK cells ex vivo without stimulation

Natural killer (NK) cells have been studied extensively in humans and mice for their vital role in the vertebrate innate immune system. They are known to rapidly eliminate tumors or virus infected cells in an immune response utilizing their lytic properties. The natural…

Department of Health and Social Care’s UK Vaccine Network funding awarded to Pirbright to aid Nipah virus vaccine development

Pirbright researchers have been awarded £389,089 to develop a Nipah virus vaccine that could protect pigs and prevent disease in humans. This funding was provided by the UK government’s UK Vaccine Network (UKVN) and will be delivered by Innovate UK. The Institute’s award is…

Pirbright’s ground-breaking research explores how pig immune system fights flu

Pirbright scientists investigate the pig’s immune response to flu and identify specific cells which are important for fighting infection and for long term protection against influenza infection. It is hoped the findings will shed more light on human response to flu and help…

Pirbright’s ground-breaking research explores how pig immune system fights flu

Pirbright scientists investigate the pig’s immune response to flu and identify specific cells which are important for fighting infection and for long term protection against influenza infection. It is hoped the findings will shed more light on human response to flu and help…

Pirbright’s ground-breaking research explores how pig immune system fights flu

Pirbright scientists investigate the pig’s immune response to flu and identify specific cells which are important for fighting infection and for long term protection against influenza infection. It is hoped the findings will shed more light on human response to flu and help…

Pirbright’s ground-breaking research explores how pig immune system fights flu

Pirbright scientists investigate the pig’s immune response to flu and identify specific cells which are important for fighting infection and for long term protection against influenza infection. It is hoped the findings will shed more light on human response to flu and help…

Scientist in a white lab coat

Pirbright celebrates our female scientists on International Day of Women and Girls in Science

11 February 2022 marks the 7th International Day of Women and Girls in Science. To highlight the important contribution our female scientists have made both to the Institute and to our global research in protecting animal and human health, we have been speaking to them about…

Lumpy skin disease

Laboratory diagnosis of lumpy skin disease (LSD): Instructor-led

Lear about lumpy skin disease virus, how to isolate and apply diagnostics.